基质金属蛋白酶MMP-2、MMP-9与类风湿性关节炎关节破坏的关系  

Association of serum MMP-2 and MMP-9 and progression of joint damage in early rheumatoid arthritis

作　　者：吴振彪[1] 卢宁[1] 王彦宏[1] 史战国[1] 樊春梅[1] 贾筠[1] 刘玲[1] 冷南[1] 朱平[1] 

机构地区：[1]第四军医大学西京医院临床免疫科,西安710032

出　　处：《中国免疫学杂志》2006年第3期260-262,共3页Chinese Journal of Immunology

基　　金：国家863资助项目(2001AA215061)

摘　　要：目的:观察血清基质金属蛋白酶MMP-2、MMP-9与类风湿性关节炎患者(Rheumatoid arthritis,RA)关节破坏的关系。方法:用双抗体夹心ELISA法测定90例未经治疗的早期RA患者及20例健康人血清中MMP-2、MMP-9,并分析其与RA患者X线表现积分(ΔLarsen)及健康评分(ΔHAQ)、CRP的关系。结果:血清MMP-2、MMP-9水平与C反应蛋白(CRP)、ΔLarsen、ΔHAQ显著相关,其相关系数及P值分别为r=0·40和0·46,P<0·01;r=0·28和0·31,P<0·05;r=0·30和0·34,P<0·01。18例最初CRP正常的患者,MMP-2及MMP-9水平与观察12个月后出现关节侵蚀改变相关(r=0·59和0·48,P<0·05)。回归分析发现,最初无骨侵蚀改变的患者,Larsen积分显示的骨侵蚀进展与MMP-2含量密切相关(r=0·32,P<0·01)。结论:血清MMP-2、MMP-9水平与RA患者的病情活动及早期关节的骨侵蚀显著相关,可以作为无骨破坏的早期RA患者出现骨侵蚀的有益预测指标。Objective：To investigate the correlation of serum MMP-2 and MMP-9 with the progression of joint damage in early rheumatoid arthritis. Methods：Serum MMP-2 and MMP-9 in ninety patients with early RA and 20 normal controls were tested with a douhle-antibedy enzyme-linked immunosorhent assay. The correlation between serum MMP-2 and MMP-9 and Larsen score（△Lamen） and Health Assessment Questionnaire（△HAQ） over the first 12 monthswas analysed. Results：Serum levels of MMP-2 and MMP-9 correlated significantly with C-reactive protein （CRP） （r = 0. 40 and 0. 46, P 〈 0. 01 ）, △HAQ （r = 0. 28 and 0. 31,P 〈 0. 01 ） and △Larsen （r =0. 30 and 0. 34, P 〈 0. 05） respectively. Analysis of the group of patients with a normal CRP showed correlation of MMP-2 and MMP-9 with the presence of erosive disease（ r = 0. 59 and 0. 48 respectively,P 〈 0. 05）. Logistic regression analysis in the patients who were non-erosive at presentation,showed that the strongest correlation with progression in Larsen score was the MMP-2 level（ r = 0. 32, P 〈0. 01）. Conclusion： Serum MMP-2 and MMP-9 levels correlate with disease activity and early progression of joint damage. They may be a valuble predictor of the progression of erosive disease in patients who are not erosive at presentation.

关 键 词：血清MMP-2 MMP-9 早期类风湿性关节炎 Larsen积分 骨侵蚀 

分 类 号：R593.22[医药卫生—内科学]