肾RI及尿β_2-MG和NAG在高能冲击波致肾损伤中测定的意义  

Changes in vascular resistance index and the levels of NAG and β_2-MG before and after high energy shockwave-induced renal damage

作　　者：罗晓辉[1] 陈兴发[1] 盛斌武[1] 王新阳[1] 周星[1] 艾红[2] 贺大林[1] 

机构地区：[1]西安交通大学医学院第一附属医院泌尿外科研究所,陕西西安710061 [2]西安交通大学医学院第一附属医院B超室,陕西西安710061

出　　处：《现代泌尿外科杂志》2006年第2期78-80,共3页Journal of Modern Urology

摘　　要：目的探讨肾血管阻力指数(RI)及尿β2-MG,NAG在高能冲击波致肾损伤中测定的意义。方法将40只雄性家兔随机分为两组:电磁碎石组、液电碎石组。每组再分为A、B两组,分别冲击1 000次和1 500次。分别于冲击前和冲击后不同时间收集尿标本检测β2-MG,NAG;彩超测肾RI。结果冲击后24 h,72 h肾RI及尿β2-MG,NAG显著升高(P<0.01)。冲击后1 500次组升高幅度显著高于1 000次组(P<0.01)。电磁碎石组和液电碎石组波源之间无显著差异(P>0.05)。结论肾RI及尿β2-MG,NAG可作为冲击波致肾脏损伤的检测指标。冲击次数的控制可以减轻肾损伤。Objective To investigate the effect of resistance index by continuously ultrasonographic monitor and β2 -MG, N-acetyl-β-D-glucosam in idase （NAG） in urine before and after ESWL in the renal damage caused by extracorporeal shock wave lithotripsy（ESWL）. Methods A total of 40 rabbits were randomly divided into two groups： electromagnetic lithotripter group and electro hydraulic lithotripter group. Each group was divided into two sub groups： A group（1 000） and B group （1 500）. RI and β2-MG, NAG were detected before and after ESWL in various time. Results 72 hours after ESWL, the level of RI, β2-MG and NAG increased obviously （P〈0.0l）. The increase of data in group A were significantly lower than those in group B （P〈0.01）. The increase of data in the electromagnetic group were not significantly different from those in the electro hydraulic group（P〉0.05）. Conclusion RI, β2-MG and NAG might be effective makers to measure the renal damage by ESWL. Control of the number of ESWL impulse can lessen the damage of kidney.

关 键 词：肾损伤 高能冲击波 RI Β2-MG NAG 

分 类 号：R692.39[医药卫生—泌尿科学]