脱水穿心莲内酯二琥珀酸半酯的合成工艺改进  

Improved synthesis of dehydroandrographolide succinate

作　　者：胡士高[1] 柏俊[1] 刘燕[1] 

机构地区：[1]安徽省药物研究所,安徽合肥230022

出　　处：《安徽医药》2006年第3期173-174,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：以穿心莲内酯在氮气保护下加入无水吡啶、琥珀酸酐、无水亚硫酸钠，控温在70～80％反应生成炎琥宁（脱水穿心莲内酯二琥珀酸半酯钾钠盐）的重要中间体脱水穿心莲内酯二琥珀酸半酯，总收率为41．7％。操作工序简便，生产成本大大降低，收率高。Dehydroandrographolide succinate, a key intermediate of potassium sodium dehydroandroan drographolide succinate, was prepared by andrographolide and succinic anhydride,which were protected with nitrogen,in dry pyridine at 70 ～ 80℃ for 2 h using sodium sulfite as reducing agent with yield of 41.7%.

关 键 词：脱水穿心莲内酯二琥珀酸半酯 炎琥宁 工艺改进 

分 类 号：TQ461[化学工程—制药化工]