γ-聚谷氨酸降解影响因素及其生物降解性能的研究  

Influence effects and performance of γ-PGA degradability

作　　者：佟盟[1] 徐虹[1] 王军[1] 

机构地区：[1]南京工业大学制药与生命科学学院,江苏南京210009

出　　处：《南京工业大学学报（自然科学版）》2006年第1期50-53,共4页Journal of Nanjing Tech University(Natural Science Edition)

基　　金：国家"十五"攻关项目(2004BA313B12-1);江苏省自然科学基金(BG2005042)

摘　　要：为开发制备低相对分子质量γ聚谷氨酸的最佳方法,在不同温度、pH值条件下水解γ聚谷氨酸,利用凝胶色谱法测定不同水解时间的相对分子质量,实验表明:高温和偏酸或偏碱环境均有利于γ聚谷氨酸的降解,最优的降解条件为低pH的酸性环境下高温加热;采用TOC法研究γ聚谷氨酸的生物降解性能,其10 d降解率在30%以上,28 d降解率在70%以上,参照OECD 301标准,属于易生物降解高分子聚合物。The optimal method of preparing low relative molecular weight γ-PGA was carried out. γ-PGA was hydro-lyzed at different temperatures and pH values, relative molecular weight of it was measured by means of GC. Theresults showed that acid, alkaline and high temperature accelerated the hydrolyzation of γ-PGA. The optimal hydrolysis condition was lower pH value and higher temperature. The biodegradability of γ-PGA was measured bymeans of TOC, the biodegradation ratio was higher than 30% after 10 days,70% after 28 days. According toOECD 301 standard, γ-PGA was an easily biodegradable polymer.

关 键 词：Γ-聚谷氨酸 降解性 凝胶色谱 温度 PH 总有机碳 

分 类 号：TQ033[化学工程]