电针治疗肠易激综合征大鼠作用观察  

The therapeutic effects of electro-acupuncture on irritable bowel syndrome in rats

作　　者：李为民[1] 崔可密[1] 吴根诚[1] 

机构地区：[1]复旦大学上海医学院中西医结合系

出　　处：《上海针灸杂志》2006年第3期43-47,共5页Shanghai Journal of Acupuncture and Moxibustion

基　　金：上海市科委课题资助(04dz19836-04);国家重点基础研究发展计划973计划课题资助(2005CB523306)

摘　　要：目的利用肠易激综合征大鼠模型,观察针刺治疗慢性内脏痛敏的作用规律,为临床提供治疗的科学依据。方法采用新生幼鼠制作了IBS慢性内脏痛敏模型,观察大鼠腹部撤回反射(AWR)和腹直肌内肌电(AEMG)变化,探讨单次电针、多次电针和不同电针次数对慢性内脏痛敏的治疗效应。结果成年IBS大鼠AWR评分和AEMG诱发放电均明显增强,单次电针可以明显降低AWR评分和AEMG诱发放电,维持时间至停针后90 m in;多次电针具有累加效应,隔日电针连续2次后治疗效果明显,4次后达到最大,停止电针后镇痛效应仍可以维持一段时间,维持时间随着治疗次数的增加而延长。结论电针对肠易激综合征的慢性内脏痛敏具有良好的即刻和累加治疗作用。Objective To find out the therapeutic effect of acupuncture on chronic visceral hyperalgesia in irritable bowel syndrome （IBS） model of the rat, and provide scientific reference for acupuncture treatment clinically. Methods IBS model was developed in the rat from neonatal age. Behavioral test of abdominal withdraw reflex （AWR） and electrophysiological recording of abdominal rectus abdominis electromyogram （AEMG） were employed in order to find out the immediate and cumulative effects of acupuncture on chronic visceral hyperalgesia. Results The AWR score and discharge of AEMG were significantly increased in IBS model rats. Single electroacupuncture （EA） treatment significantly decreased AWR score and evoked AEMG while repetitive EA treatments played cumulative roles in decreasing AWR score and evoked AEMG. Conclusion EA can relieve IBS induced chronic visceral hyperalgesia and its effect is parallel to the times of EA applied.

关 键 词：慢性内脏痛敏 电针 肠易激综合征 腹部撤回反射 腹直肌肌电 大鼠 

分 类 号：R2-03[医药卫生—中医学]