软珊瑚Sinularia papillosa的次生代谢产物研究  

Studies on the Secondary Metabolites of the Soft Coral Sinularia papillosa

作　　者：张翠仙[1] 曾陇梅[2] 

机构地区：[1]广州中医药大学中药学院,广州510405 [2]中山大学化学与化工学院,广州510275

出　　处：《中药新药与临床药理》2006年第2期132-134,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金项目(29932030)

摘　　要：目的研究海洋动物软珊瑚Sinulariapapillosa的次生代谢产物,寻找药物先导化合物。方法利用柱层析和现代分离方法进行分离、纯化,结合波谱学(UV,IR,NMR,MS等)研究,鉴定其次生代谢产物的物质结构及其生理活性。结果从软珊瑚乙酸乙酯部分又分离得到2个白色无定型粉末状化合物,通过波谱分析确定其为:(1)孕甾-5,20-二烯-3β-醇-3-O-α-L-吡喃岩藻糖苷;(2)1-(17Z-二十四碳烯基)-甘油醚。结论化合物1和2均为首次从该属软珊瑚中分离到,对于珊瑚分类学和甾类化合物的生源学具有一定参考意义。Objective Secondary metabolites of the soft coral were studied to find out the lead compound of the drugs. Methods Compounds from the soft coral Sinularia papillosa were obtained by column chromatography and modern isolation methods and their structures were identified by spectrum of UV, IR, NMR, MS, et al. Results Two white amorphous compounds were obtained from the EtOAc （ethyl acetate） fraction, and their structures were identified as pregn - 5, 20 - dien - 3β - ol - 3 - O - α - L - fucopyranoside （ 1 ） and 1 - （ 17Z - tetracose - nyloxy） - 1, 2 - propanediol （2） by spectral analysis. Conclusion Two compounds are first isolated from the soft coral genus Sinularia, which will be beneficial for the taxonomy of the soft coral and for biogenesis of steroids.

关 键 词：软珊瑚 SINULARIA papillosa 次生代谢产物 孕甾糖苷 甘油醚 波谱分析 

分 类 号：R284.1[医药卫生—中药学]