小青龙汤和麻黄汤抗组胺作用  

Antihistamine Action of Small-blue-dragon Decoction and Mahuang Decoction

作　　者：阮岩[1] 李笋[1] 封彦蕾[1] 陈蔚[2] 

机构地区：[1]广州中医药大学第一附属医院耳鼻咽喉科,广州510405 [2]广州中医药大学附属祁福医院,广州510200

出　　处：《中药新药与临床药理》2006年第2期144-147,共4页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：目的利用组胺皮肤试验了解中药抗组胺机理,比较中西药抗组胺作用的异同。方法将45例健康志愿者分为小青龙汤组,麻黄汤组,氯雷他定组和安慰剂组,各组在用药前及用药后2,5,24h进行不同浓度的组胺皮肤试验,皮试后15min观察并记录风团及红晕的面积,绘制剂量-反应曲线。结果风团和红晕面积比较,小青龙汤、麻黄汤组服药后2,5,24h和服药前差异无显著性(P>0.05)。氯雷他定组服药后2,5,24h和服药前差异有显著性(P<0.05)。结论小青龙汤和麻黄汤不能直接抑制组胺,而可能是抑制肥大细胞脱颗粒作用,减少组胺的分泌。Objective To investigate the antihistamine mechanism of Chinese herbal medicine by histamine - skin experiments and to campare the effective similarities and differences between the Chinese herbal medicine and the western medicine. Method The 45 healthy volunteers were divided into 4 groups： Small- blue- dragon Decoction group, Mahuang Decoction group, loratadine group and placebo group. In each group, histamine skin tests （histamine concentrations with 20.0, 7.3 , 2.7 , 1.0 mmol/L ） were performed before treatment and after treatment for 2, 5, 24 hours. 15 minutes later, after skin tests, wheal and flare areas were measured, the AUDRC （ area under dose-response curve, AUDRC） were drawed. Result Compared with pre - administration, the wheal and flare areas have no significant difference in Small- blue- dragon Decoction group and Mahuang Decoction group （P 〉 0.05）, while loratadine group shows a highly significant treatment efficacy （ P 〈 0.05 ）. Conclusion Probably the Chinese herbal medicine is to repress the mastocyte taking off the grain function and to reduce histamine secretion sequentially.

关 键 词：小清龙汤 麻黄汤 抗组胺作用 皮肤试验 

分 类 号：R285.6[医药卫生—中药学]