正交试验优选黄连散中葛根等成分的提取工艺  

Optimization of Extraction Technology for Pueraria and Other Active Component in Huanglian Powder with Orthogonal Test

作　　者：陈礼明[1] 刘圣[1] 唐丽琴[1] 李矗[1] 

机构地区：[1]安徽省立医院药剂科,合肥市230001

出　　处：《中国药房》2006年第6期415-417,共3页China Pharmacy

基　　金：安徽省重点科技项目(01023018)

摘　　要：目的:筛选黄连散中葛根、麦冬、枇杷叶的最佳提取工艺。方法:采用正交设计试验,以葛根素总量为指标,考察溶剂浓度、溶剂用量倍数、提取时间、提取次数4种因素对提取结果的影响。结果:最佳提取工艺为60%乙醇、8倍量、提取3次、每次60min。结论:该工艺所得浸膏得率和葛根素含量均较高,稳定、重现性好,可为黄连散的生产提供参考数据。OBJECTIVE： To optimize the extraction technology of pueraria, ophiopogonis, and loquat leaf. METHODS： Orthogonal test was carried out. The influence of concentration of solvent, the dosage of solvent, time length of extraction, and frequency of extraction on extraction results were investigated by using the content of pueraria as index. RESULTS： The optimal extraction technique was to extract pueraria in 60% alcohol 8 times the weight of herbal medicine for 3 times, with 60 minute for each time. CONCLUSION： High yield of extractum and high content of pueraria are obtained with the present technology. The results are stable and replicable, which can provide reference for preparation of Huanglian powder.

关 键 词：黄连散 正交试验 葛根素 提取工艺 

分 类 号：R284.2[医药卫生—中药学]