产超广谱β-内酰胺酶细菌感染的耐药性分析  

Bacterial Infections that with Extended Spectrum β Lactamases(ESBLs) Production: Drug Resistance Analysis

作　　者：张丽华[1] 于庆萍[1] 岳梅林[1] 

机构地区：[1]内蒙古医学院第三附属医院,包头市014010

出　　处：《中国药房》2006年第6期445-446,共2页China Pharmacy

摘　　要：目的:了解产超广谱β-内酰胺酶(ESBLs)细菌感染的发生率及耐药特征,为临床用药提供参考。方法:对我院2001年～2004年分离出的大肠埃希菌和肺炎克雷伯菌进行ESBLs检测,比较各年感染的发生率,并采用K-B纸片法进行药敏试验。结果:产ESBLs的大肠埃希菌、肺炎克雷伯菌感染发生率呈逐年上升趋势;产ESBLs的大肠埃希菌、肺炎克雷伯菌对亚胺培南的耐药率最低,分别为1.9%、2.9%,其次是哌拉西林/他唑巴坦、阿米卡星,分别为26.2%、20.5%和33.6%、35.2%。结论:碳青酶烯类抗生素可作为产ESBLs细菌感染的首选药。OBJECTIVE ： To study the incidences and drug - resistance characteristics of bacteria infections that with ES- BLs production for references of clinical medication.METHODS： Escherichia coli and Klebsiella pneumoniae isolated from 2001to 2004 were subjected to ESBLs detection .The incidence of infection of each year was compared and the susceptibility test was performed by K - B paper disk method.RESULTS： Bacterial infection incidences caused by ESBLs - producing E.coli and Klebsiella pneumoniae increased year by year.Strains with ESBLs producution showed lower sensitivity to antibiotics than those without.E.coli and K.pneumoniae that with ESBLs productions showed the lowest drug resistance rates, which stood at 1.9% and 2.9%, respectively.Their drug resistances to piperacillin/tazobactam were 26.2% and 20.5%, respectively and 33.6% and 35.2%, respectively to amikacin.CONCLUSION： Carbapenem antibiotics are the optimal choice in the treatment of bacterial infections that with ESBLs production.

关 键 词：超广谱Β-内酰胺酶 细菌 耐药性 抗菌药物 

分 类 号：R978.11[医药卫生—药品] R969.3[医药卫生—药学]