淫羊藿甙抗大鼠雄激素部分缺乏的实验研究  

Experimental studies on anti-Partial androgen deficiency effects of icariin

作　　者：章振保[1] 杨庆涛[1] 

机构地区：[1]汕头大学医学院第二附属医院泌尿外科,汕头515041

出　　处：《中国男科学杂志》2006年第3期47-50,共4页Chinese Journal of Andrology

摘　　要：目的探讨淫羊藿甙对雄激素部分缺乏大鼠的保护作用。方法以环磷酰胺造成生殖系统受损、雄激素部分缺乏大鼠模型,灌胃淫羊藿甙(1CA)和皮下注射丙酸睾酮(T)7d后,检测血清T、LH、FSH含量和血清BGP、StrACP含量；以HE染色和TUNEL检测,光镜下观察睾丸组织、阴茎海绵体平滑肌细胞变化情况。结果(1)血清T水平：T组(34.96±11.42)ng/ml和ICA组(10.94±2.04)ng/ml明显高于空白(C)组(3.0141±0.4131)ng/ml和模型(M)组(0.79+0.45)ng/ml,且T组高于ICA组,C组高于M组(P＜0.05)；(2)血清BGP水平：T组(4.50±1.70)ng/ml和ICA组(3.44±0.51)ng/ml明显高于C组(1.82±0.50)ng/ml和M组(1.22±0.50)ng/ml(P＜0.05)；(3)血清StrACP活力水平：T组(25.73±7.57)U/L和ICA组(19.99±8.63)U/L明显低于C组(51.32±14.16)U/L和M组(64.89±12.57)U/L,且C组低于M组(P＜0.05)；(4)阴茎海绵体平滑肌细胞的凋亡率：T组(22.65±5.17)%和ICA组(34.26±3.45)%明显低于M组(48.28±6.74)%,(P＜0.05)。结论淫羊藿甙具有抗雄激素部分缺乏的作用,可用于PADAM的治疗。Objective To explore the protective effects oflcariin on partial androgen deficiency rat. Methods Reproduction system of 15 months male rat was first damaged by CYP. After ig. Icariin and ip. Propyltestosterone, the content of serum T, LH, FSH, BGP and StrACP were determined. The change of histology of the testis and the penis were observed by microscope with the method of H-E staining and TUNEL method respectively. Results （1） As to the contents of serum T, T group 04,96±11.42）ng/ml and ICA group （10.94±2.04）ng/ml were statistically higher than C group 0.01±0.41）ng/mland M group （0.79±0.45）ng/m1. Furthermore, Tgroup as higher than ICA group, and C group as higherthan M group （P〈0,05）; （2） Serum BGP, T group （4.50±1,70）ng/ml and ICA group （3.44±0.51） ng/ml were statistically higher than C group （1. 82±0.50）ng/ml and M group （1.22±0.50） ng/ml （P〈0.05）; （3）Serum Str ACP, T group （25.73±7.57）U/L and ICA group （19.99±8.63）U/L were statistically lower than C group（51.32±14.16）U/L and M group（64.89±12.57）U/L, Furthermore, C group was lower than M group （P〈0,05）; （4）As to the cell apoptosis rate in rat penis, T group （22.65±5.17）% and ICA group（34.26±3.45）%were statistically lower than M group （48.28±6.74）%, （P〈0.05）. Conclusion lcariin possesses theanti-partial androgen deficiency effects, and is beneficial to PADAM.

关 键 词：淫羊藿甙 雄激素类 睾酮 

分 类 号：R697.22[医药卫生—泌尿科学]