益肾活血方对家兔血瘀模型纤溶指标与血液流变学影响的研究  

Study on the function of decoction for invigorating the kidney and improving blood circulation to thrombosis on rabbit blood stasis model

作　　者：詹小萍[1] 孙梅[1] 金晓滢[1] 金晨宇[1] 徐锡鸿 秦光明[1] 鲍军[1] 

机构地区：[1]浙江大学医学院附属二院,浙江杭州310009 [2]浙江中医研究院,浙江杭州300163

出　　处：《中国中药杂志》2006年第5期411-413,共3页China Journal of Chinese Materia Medica

基　　金：浙江省中医管理局立项课题(96036)

摘　　要：目的:研究益肾活血方对家兔血瘀模型纤溶指标与血液流变状态的影响,并探讨其机制。方法:兔30只,随机分为正常组、模型组、益肾活血方大、小剂量组、血栓宁组,各组相应处理后分别取静脉血检测组织型纤溶酶原激活剂(t-PA)、纤溶酶原激活剂抑制物(PAI)、纤维蛋白原(Fbg)、D-二聚体(DD),血黏度。结果:t-PA,PAI,Fbg,DD,红细胞压积(H)、全血表观黏度(ηа)、血浆黏度(ηр),正常组、益肾活血大、小剂量组与模型组比有非常显著性差异(P<0.01);血栓宁组与模型组比有显著性差异(P<0.05,P<0.01);益肾活血大、小剂量组与血栓宁组比有显著性差异(P<0.05);益肾活血大剂量组与小剂量组比无显著性差异(P>0.05)。结论:益肾活血大、小剂量组及血栓宁组对血瘀模型纤溶指标与血液流变状态均有影响,且均强于血栓宁组。Objective： To evaluate the effect of decoction for invigorating the kidney and improving blood circulation to thrombosis and pathology on rabbit blood stasis model. Method： Thirty rabbits were ramdomly divided into normal group,model group, high dose group, low dose group and Xue Shuan Ning group. Tissue-type plasminogen activator （t-PA）, plasminogen activator inhibitor（PAI）, fibrinogen（Fbg） and D-dimer（DD） were investigated after those rabbits had been treated, one rot was solected randomly from each group to observe pathological changes. Result： There were significant differences in t-PA, PAI, Fbg and DD between normal group and other groups is very obvious （ P 〈 0. 01 ）. Between groups of high dose low dose Xue Shuan Ning and model, the statistical differeces were significant, as well as between groups of high dose, low dose and Xue Shuan Ning groups（ P 〈 0.05）. However, there was no statistical difference between high dose group and high dose group（ P 〉 0. 05）. The pathological changes in model group were most serious, those in Xue Shuan Ning were less serious. There were slight pathological changes in high dose group and low dose group. Conclusion： Models ware made successfully. High dose group and low dose group have stronger effect on thrombosis than Xue Shuan Ning group.

关 键 词：益肾活血 血瘀模型 纤溶指标 血液流变学 

分 类 号：R285.5[医药卫生—中药学]