高尿酸血症患者血清超灵敏C反应蛋白水平与胰岛素抵抗  

The Level of Serum High Sensitive C-reactive Protein and the Resistance of Insulin in Patients with Hyperuricemia

作　　者：李晨钟[1] 薛耀明[1] 高方[1] 汪敏[1] 

机构地区：[1]南方医科大学附属南方医院内分泌代谢科,广东省广州市510515

出　　处：《中国全科医学》2006年第6期451-452,455,共3页Chinese General Practice

基　　金：广东省卫生厅基金(A2000378)

摘　　要：目的探讨高尿酸血症患者血清超灵敏C反应蛋白(hs-CRP)水平与机体胰岛素敏感度、胰岛素分泌功能的关系。方法运用高灵敏酶联免疫吸附法检测41例高尿酸血症患者和20例健康对照者的血清hs-CRP水平,同时检测血糖和血清胰岛素水平,并计算稳态模型胰岛素抵抗(HOMA IR)指数和胰岛β细胞分泌(HOMA IS)指数,以反映胰岛素敏感度和胰岛细胞功能。结果高尿酸血症患者的血清hs-CRP水平和HOMAIR指数显著高于正常对照者(P均<0.01),HOMAIS指数低于正常对照者(P<0.01)。高尿酸血症组中有痛风症状的患者其血清hs-CRP水平显著高于无痛风症状者(P<0.01)。线性相关分析显示,高尿酸血症患者的血清hs-CRP水平与体重指数(BMI)、血尿酸、24h尿尿酸和HOMAIR指数呈正相关(均P<0.01)。结论高尿酸血症患者血清hs-CRP水平高于正常人,并与其胰岛素抵抗的发生、发展有密切关系。Objective To investigate the relationship between serum high sensitive C - reactive protein （ hs - CRP） levels and insulin sensitivity or islet function in patients with hyperuricemia. Methods Serum hs - CRP level was determined with highly sensitive enzyme - link immune absorption assay （ELISA） method in 41 patients with hyperuricemia and 20 normal controls, meanwhile plasma glucose and serum insulin were measured. Moreover, homeostasis model analysis （HOMA） insulin resistance index （HOMA IR） and HOMA -islet secretion index （HOMA IS） were calculated to reflect insulin sensitivity and islet function. Results In the patients with hyperuricemia, serum hs- CRP and HOMA IR index were higher than those in the normal group （ P 〈 0. 01 ） , HOMA IS index were decreased as compared with normal subject （ P 〈 0. 01 ）. Moreover, serum hs -CRP was higher in hyperuricemia patients accompany with gout than that in symptomless hyperuricemia patients （ P 〈 0. 01 ）. The liner regression analysis in hyperuricemia patients showed that serum hs - CRP was positively correlated with body mass index, HOMA IR index, serum uric acid and urine uric acid level respectively （ P 〈 0.01 ）. Conclusion Serum hs - CRP level is higher in the patients with hyperuricemia than that in normal subjects, and play an important role in the onset and development of insulin resistance.

关 键 词：C反应蛋白 胰岛素抵抗 高尿酸血症 

分 类 号：R587[医药卫生—内分泌] R589.7[医药卫生—内科学]