急性脑卒中血清髓鞘碱性蛋白含量测定的临床研究  

Clinical study of serum myelin basic protein level detecting in acute apoplexy

作　　者：杨荣椿 陈肇杰 李克乐 肖克安 黄卫明[1] 曾桂胜 

机构地区：[1]广东省中山市黄圃人民医院神经内科,528429

出　　处：《神经疾病与精神卫生》2006年第1期9-10,共2页Journal of Neuroscience and Mental Health

基　　金：2004年广东省中山市科委立项(编号:2004A116)

摘　　要：目的探讨急性脑卒中血清髓鞘碱性蛋白(MBP)的含量变化及临床意义。方法采用MBP-ELISA双抗夹心法进行定量检测对脑出血30例、脑梗塞30例及健康对照组30例测定血清髓鞘碱性蛋白(MBP)的含量水平。结果脑出血、脑梗死组的血清髓鞘碱性蛋白的含量均明显高于健康对照组(P<0.01),但脑出血、脑梗塞组结果相似。结论测定脑卒中患者血清髓鞘碱性蛋白含量的变化可以从生化指标来反映脑实质损害与血脑屏障破坏的程度,结合影像学对判断脑卒中的病情和预后有较好的临床实用价值。Objective To probe the level changing of serum myeli basic protein （MBP） and the clinical significance in acute apoplexy. Methods By MBP-ELISA, the serum level of MBP in 30 cases of cerebral hemorrhage patients, 30 cases of cerebral infarction patients and 30 controls were detected. Results The levels of MBP in patients with cerebral hemorrhage and cerebral infarction were higher obviously than that of controls. Conclusions Detecting of serum MBP levels changing in apoplexy patients can indicate the degrees of brain damage and blood-brain barrier damage, combined with imageology, it can help us to judge the condition and prognosis of apoplexy.

关 键 词：脑卒中 脑出血 脑梗死 髓鞘碱性蛋白 

分 类 号：R743.3[医药卫生—神经病学与精神病学]