抗HCV阳性的各类肝病患者HCV-RNA、抗-GOR及其与ALT关系  

Relationship between HCV-RNA,anti-GOR and ALT in Hepatitis with anti-HCV positive

作　　者：俞小忠[1] 李保仝[2] 邵海枫[2] 武建国[2] 

机构地区：[1]中国人民解放军第123医院检验科,安徽蚌埠233015 [2]南京军区南京总医院检验科,江苏南京210002

出　　处：《蚌埠医学院学报》2006年第2期180-181,共2页Journal of Bengbu Medical College

摘　　要：目的:观察HCV感染者抗-GOR、HCV-RNA及其与丙氨酸氨基转移酶(ALT)的关系。方法:对69例抗-HCV阳性的慢性丙型肝炎、肝硬化、肝癌患者检测HCV-RNA、抗-GOR水平,并与ALT水平进行比较。结果:慢性丙型肝炎、肝硬化、肝癌患者HCV-RNA阳性率分别为59.4%、61.9%和56.3%;抗-GOR的阳性率分别为71.9%、66.7%和68.8%。ALT>40 u/L组与ALT≤40 u/L组抗-GOR和HCV-RNA阳性率均有显著性(P<0.005和P<0.05)。结论:抗-GOR检测有助于HCV的诊断,抗GOR阳性率与ALT水平相关。Objective： To observe the relationship between HCV-RNA, anti-GOR and alanine arninotransber（ALT） in patients with various hepatic diseases resulted from HCV. Serum HCV-RNA, anti-GOR and ALT levels of 69 cases of various hepatic diseases with anti-HCV positive were measured and compared. Methods：Anti-HCV and anti-GOR were measured by ELISA and HCV-RNA was determined by PCR. Results：The positive rates of HCV-RNA and anti-GOR were 59.4% ,61.9% ,56.3% and 71.9% 66.7%, 68.8% respectively in the patients with chronic hepatitis C, hepatocirrhosis, and hepatocellular carcinoma. The positive rate of anti-GOR was significantly higher in the ALT 〉 40 u/L group than that in the ALTo〈40 u/L group（ P 〈 0. 005 and P 〈 0.05）. Conclusions： Detection of anti-GOR is of value for the diagnosis of HCV. The positive rate of anti-GOR correlates with the activity of ALT.

关 键 词：丙型肝炎 病毒性 合成肽 丙氨酸氨基转移酶类 

分 类 号：R512.63[医药卫生—内科学]