平行催化氢波法测定双氯酚酸钾  

Polarographic Determination of Diclofenac Potassium Using Its Parallel Catalytic Hydrogen Wave

作　　者：马淮凌[1] 徐茂田[1] 凌翠霞[1] 黄华伟[1] 

机构地区：[1]商丘师范学院化学系,河南商丘476000

出　　处：《分析测试学报》2006年第2期39-42,共4页Journal of Instrumental Analysis

基　　金：河南省自然科学基金资助项目(0511020300)

摘　　要：建立了灵敏快速测定双氯酚酸钾的新方法。在HAc—NaAc（pH5．0±0．1）支持电解质中，双氯酚酸钾产生一催化氢波，峰电位Vv=-1．15V（vs．SCE）。加入H2O2后，该催化氢波被催化，峰电流增加约40倍，峰电位基本不变，产生一较灵敏的平行催化氢波。其二阶导数峰峰电流Ip″与双氯酚酸钾浓度在1．0×10^-7～-5．0×10^-6mol·L^-1范围内呈线性关系（r=0．9986，n=8），检出限为5．0×10^-8mol·L^-1。该方法可用于药物制剂中双氯酚酸钾含量的测定。A new method for the rapid determination of diclofenac potassium was developed. The diclofenac potassium yielded a catalytic hydrogen wave whose peak potential was -1.15 V（vs. SCE） in 0.25 mol · L^-1 HAc -NaAc （pH 5.0 ±0. 1 ） supporting electrolyte. In the presence of 1.0 × 10^-2 mol · L^-1 H2O2, a more sensitive parallel catalytic hydrogen wave was produced. The peak current increased by 40 times and the peak potential remained almost the same. The second derivative peak current of the parallel catalytic hydrogen wave was rectilinear to the diclofenac potassium concentration in the range of 1.0 × 10^-7 mol · L^-1 and 5.0 × 10^-6 mol · L^-1 （r =0. 998 6, n =8）. The limit of detection was 5.0 × 10^ -8 mol · L^ -1. The proposed method can be applied to the determination of diclofenac potassium in pharmaceuticals without any preliminary separation.

关 键 词：双氯酚酸钾 过氧化氢 催化氢波 平行催化氢波 单扫描示波极谱法 

分 类 号：O657.14[理学—分析化学]