冠心病人单个核白细胞表面粘附相关蛋白的表达  

Study on the Expression of Adhesion Related Proteins on Mononuclear Cells in patients with Coronary Heart Disease

作　　者：安靓[1] 李进[1] 黄剑 刘小蓉 

机构地区：[1]第一军医大学组织胚胎学教研室,中国人民解放军细胞生物学实验室

出　　处：《中国动脉硬化杂志》1996年第1期12-15,共4页Chinese Journal of Arteriosclerosis

摘　　要：采用免疫组织化学与形态计量学的方法，观察了正常人和冠心病人外周血单个核细胞表面Ｖｎ、ＣＤ４４和ＣＤ１１ｂ三种有代表性的粘附相关蛋白的分布及量的变化。结果表明，冠心病组单个核细胞粘附相关蛋白的表达量明显高于正常人群组，三种粘附相关蛋白的在达量亦有明显差异，其表达量依次为，ＣＤ４４，Ｖｎ，ＣＤ１１ｂ。在冠心病组，三种粘附相关蛋白升高的程度不同，其中ＣＤ１１ｂ升高最为明显，其次为ｖｎ和ＣＤ４４。作者对粘附相关蛋白表达在动脉粥样硬化过程中的机制和意义进行了讨论。Aim Observed the expressive quantity and distribution of adhesion related proteins(ARP) in the mononuclear cells among the patients with coronaryheart disease (CHD) and normal people.Methods Display the distribution of CD11b, CD44and Vn on the mononuclear cells by means of immunohistochemistry and morphological metrology methods.Results The positive area of CD11b,CD44 and Vn shows pink or dark pink colour, and display a ring shape, semilunar shape, cap shape, spot-flate shape and granular shape,Quantitative analysis indicate that the Sum and Ar value increased obviously in the CHD.Conclutions The Expression of the ARP is higher in CHD group then in normal. There is a obvious difference among the three kind of proteins in expresive quantity which from high to low is CD44, Vn,CD11b. In CHD group the increase of the three ARP are different in degree, the first is CD11b, the next is Vn and then it is CD44.

关 键 词：单个核细胞 白细胞 粘附相关蛋白 冠心病 

分 类 号：R541.402[医药卫生—心血管疾病]