α-磷酸三钙骨水泥自固化制备多孔磷酸钙复相陶瓷  

PREPARATION OF POROUS CALCIUM PHOSPHATE CERAMICS BY SELF-SETTING OF α-TRICALCIUM PHOSPHATE BONE CEMENT

作　　者：蔡舒[1] 于显著[1] 许国华[2] 王彦伟[1] 肖张莹[1] 吕宏[2] 

机构地区：[1]天津大学,先进陶瓷与加工技术教育部重点实验室,天津300072 [2]上海长征医院,上海200003

出　　处：《硅酸盐学报》2006年第3期324-328,共5页Journal of The Chinese Ceramic Society

基　　金：国家自然科学基金(30170954)资助项目。

摘　　要：以聚氨酯泡沫为多孔模板，α-磷酸钙骨水泥为浆料体系，将浸渍法和骨水泥自固化特性相结合，制备大孔尺寸为200～400μm、贯穿式微孔尺寸约为1μm的多孔磷酸钙复相陶瓷支架。研究了分散剂聚丙烯酸钠对羟基磷灰石成核、生长的影响，以及烧成温度与相组成的相关性。结果表明：浆料中分散剂聚丙烯酸钠对羟基磷灰石的成核有明显抑制作用；骨水泥水化反应过程中生成的针状、片状羟基磷灰石通过交联形成微孔结构，可避免干燥时裂纹的产生；经1200℃烧结的多孔陶瓷支架由羟基磷灰石、β-磷酸三钙和少量未水化完全的α-磷酸三钙组成。Porous hydroxyapatite/β-calcium phosphate ceramic scaffolds with macropore sizes of 200-400 μm and micropore sizes of about 1 μm were prepared by coating porous polyurethane template with α- calcium phosphate bone cement （CPC） slurry, and its subsequent hydrolysis to calcium deficient hydroxyapatite （HA） during the self-setting processes is presented. The effects of sodium polyacrylate （NaPA） on the nucleation and growth of the HA crystals, and the relationship between the sintering temperature and phase constitution were studied. The results show that micropores formed by the flake-like or whiskerlike crystals of deficient HA in the CPC could prevent the formation of cracks during drying. The addition of NaPA could decrease the nucleation of HA crystals because of the steric effect. By firing the porous CPC samples at 1 200 ℃, the polyurethane foams burnt off and the CPC samples prepared at room temperature were converted into a sintered porous ceramic scaffold that was constituted of HA, β-tricalcium phosphate （β-TCP） and a small quantity of unhydrolyzed β-TCP.

关 键 词：磷酸钙骨水泥 自固化 多孔陶瓷支架 

分 类 号：TQ174.758.11[化学工程—陶瓷工业]