一氧化氮对脑室周围白质软化早产儿神经发育的影响  

The effect of inhaled nitric oxide on neurodevelopmental outcomes of premature infants with periventricular leukemalacia

作　　者：付雪梅[1] 封志纯[1] 洪小杨[1] 陈佳[1] 

机构地区：[1]南方医科大学附属珠江医院儿科,广东广州510282

出　　处：《临床儿科杂志》2006年第3期176-178,共3页Journal of Clinical Pediatrics

摘　　要：目的探讨一氧化氮(NO)在合并脑室周围白质软化(PVL)的早产儿神经发育中的作用。方法采用随机、对照实验,对合并PVL的106例早产儿,在出生后24h内随机分成吸入NO组(第1天10×10-6,以后改为5×10-6继续用6d)和对照组(吸入氧气7d),在纠正胎龄18个月时采用贝利发育量表评估其神经发育。结果吸入NO组贝利评分明显高于对照组(P<0.05),贝利评分低于70分的发生率明显低于对照组(P<0.05)。结论合并脑室周围白质软化早产儿采用吸入NO治疗,有利于促进其神经发育。Objective To study the effect of inhaled nitric oxide on neurodevelopmental outcomes of premature infants with periventricular leukemalacia （PVL）. Methods 106 premature infants （101 boys and 54 girls） with PVL were randomly divided into two groups within 24 hours after delivery. Group A, nitric oxide was inhaled （10 ppm for one day, followed by 5 ppm for six days） and group B, oxygen was given for seven days with randomized, placebo-controlled study. And they were assessed for the neurodevelopment with Bayley psychomotor development index score （PDI） and mental developmental index （MDI） in 18 months of corrected age. Results There was significant difference in the PDI and MDI between group A and group B （for group A the PDI score was 87.26±23.62 and MDI score was 68.78± 20.06,for group B the PDI score was 73.66± 28.31 and MDI score was 59.17± 24.87, all P〈0.05. And the incidence of periventricular leukomalacia in the patients with the scores less than 70 was significant higher in group B （the incidence of PDI and MDI were 24.07% and 46.30 %respectively in group A , the incidence of PDI and MDI were 42.31% and 65.38% respectively in group B）. Conclusions The inhalation of nitric oxide could improve the neurodevelopmental outcomes in the premature infants with PVL.

关 键 词：早产儿 脑室周围白质软化病 一氧化氮 神经发育 

分 类 号：R722.6[医药卫生—儿科]