早期干预对新生儿缺氧缺血性脑病预后的影响  

Early intervention and the prognosis of the neonates with hypoxic ischemic encephalopathy

作　　者：李勇[1] 程锐[1] 许植之[1] 韩玉昆[2] 周晓玉[1] 蒋小镛[1] 赵卫华[1] 钱家萍[1] 

机构地区：[1]南京医科大学附属儿童医院,江苏南京210008 [2]中国医科大学第二临床医院

出　　处：《临床儿科杂志》2006年第3期188-190,共3页Journal of Clinical Pediatrics

基　　金：国家九五攻关项目(项目编号:96.90406049)

摘　　要：目的 探讨早期干预对中、重度新生儿缺氧缺血性脑病（HIE）患儿预后的影响。方法 将74例中、重度HIE患儿分为干预组（39例）及对照组（35例），两组基本情况差异无显著性。对干预组进行系统的早期干预。结果 经3、6、9、12、18、24、36个月随访，干预组平均智能发育指数（MDI）及运动发育指数（PDI）高于对照组（P〈0．01）；对照组后遗症发生率明显高于干预组（X^2=4．4095，P〈0．05）；MDI及PDI〈80分、语言落后、社交异常干预组患儿明显低于对照组（P〈0．05～0．01）。结论 早期干预能改善HIE的预后，降低脑瘫及智能发育落后。Objective To study the effect of early intervention on neonates with hypoxic-ischemic encephalopathy （HIE）. Methods 74 case of neonates with medium and severe HIE were studied. Early systemic intervention was done for 39 cases （Group A） with 35 untreated as Group B. There was no difference in general condition between groups A and B. Results Average scores of mental development index （MDI） and physical development index （PDI） in group A were higher than that in group B at the ages of 3rd, 6th, 9th, 12th, 18th, 24th and 36th months （P 〈0.01）. The incidence of sequelae in group B was significantly higher than that in group A （X^2=4.41, P 〈 0.05）. The scores of MDI and PDI〈80, the incidence of developing mental retardation（MR）, language retardation, poor social skill were lower in group A （P〈0.05～0.01） . Conclusions The prognosis of HIE will be improved with early intervention. The morbidity of cerebral palsy and mental retardation can be decreased as well.

关 键 词：早期于预 缺氧缺血性脑病 预后 新生儿 

分 类 号：R722.1[医药卫生—儿科]