脑欣口服液对新生大鼠HIE脑细胞MDA、SOD的实验研究  

Experiment Research of Naoxin Oral Liquid Effect on New-Born rats'HIE Cerebrocell MDA and SOD

作　　者：苏保宁[1] 王旭庚[1] 马爱玲[1] 罗世杰[1] 刘晓萍[2] 白学斌[1] 

机构地区：[1]陕西中医学院,陕西咸阳712046 [2]陕西中医学院附属医院,陕西咸阳712000

出　　处：《陕西中医学院学报》2006年第2期54-55,共2页Journal of Shaanxi College of Traditional Chinese Medicine

基　　金：陕西中医学院科研基金项目(2002-240)

摘　　要：目的探讨脑欣口服液治疗新生鼠缺氧缺血性脑病的疗效及机理。方法将7日龄SD大鼠随机分为5组,即脑欣口服液组(中药组)、脑活素组(西药组)、脑欣口服液+脑活素组(中药+西药组)、HIE模型组、假手术组。每组10只。造模后用药。用比色法测量丙二醛(MDA)、超氧化物岐化酶(SOD)。结果中药组与西药组比较无差异(P>0.05);中药+西药组优于单纯中药组及西药组(P<0.05);中药组优于HIE模型组(P<0.05);中药+西药组与假手术组比较无差异(P>0.05)。结论脑欣口服液具有调节HIE大鼠脑内丙二醛,超氧化物岐化酶含量的功能。中药与西药合用优于单纯应用中药或西药。Objective To discuss Naoxin oral liquid＇s therapeutic effect and mechanism in treating new- born rats＇ hypoxic and ischemic encephalopathy. Method Divided 7 - day - old SD rats＇ into 5 groups randomly, including Naoxin oral liquid group （traditional Chinese drug group）, cerebrolysin group（western medicine group）, Naoxin oral liquid ＋ cerebrolysin gronp（traditional Chinese drug ＋ Western medicine group）,HIE model group and pseudoperation group, with 10 in each group. Drugs were administered after creation of models. Measured MDA and SOD with colorimetric method. Result There was no difference between traditional Chinese drug group and western medicine group（ P 〉 0.05 ） ; traditional Chinese group ＋ western medicine group was significantly better than simply one of the two （ P 〈 0.05） ; traditional Chinese drug group was better than HIE model group （ P 〈 0.05 ） ; no difference was observed between traditional Chinese drug group ＋ Western medicine group and pseudoperation group（ P 〉 0.05）. Conclusion Naoxin oral liquid could regulate the content of MDA and SOD in HIE rats＇ brain. Traditional Chinese drug combined with western medicine was remarkably better than simplp one of the two.

关 键 词：缺氧缺血性脑病(HIE) 丙二醛(MDA) 超氧化物岐化酶(SOID) 脑欣口服液 

分 类 号：R285.5[医药卫生—中药学]