两种方法制备肺靶向地塞米松磷酸钠微球的比较  

Comparison of Lung Targeted Microspheres Containing Dexamethasone Sodium Phosphate Prepared by Two Methods

作　　者：陶兆武[1] 叶燕青[1] 徐启勇[1] 

机构地区：[1]武汉大学中南医院呼吸内科,武汉430071

出　　处：《中国药师》2006年第4期304-307,共4页China Pharmacist

基　　金：湖北省科技攻关计划(编号:2004AA301C24)

摘　　要：目的:研究两种制备方法所制备的肺靶向地塞米松磷酸钠微球的特性,确定两种方法是否适合用于制备该微球。方法:对油／水型乳化-溶剂挥发法的工艺进行优化,以优化后的油／水型乳化-溶剂挥发法和水／油／水型乳化-溶剂挥发法制备微球,考察微球的大小、载药量、体外释药等性质。结果:两法所制的微球的平均粒径相近,载药量和体外释药特性各不相同。结论:两种方法都适合用于制备肺靶向的地塞米松微球。从载药量方面分析,优化后的油／水型乳化-溶剂挥发法较好。Objective： To study the characterizations of lung targeted microspheres prepared by two methods and to decide if theses methods are suitable for preparing the microspheres. Method： The o/w emulsification-evaporation method was optimized, then preparing microspheres hy optimized o/w and w/o/w emulsification-evaporation method. The size, the loading efficiency and the release of microspheres in vitro were observed. Result： Microspheres prepared by the two methods almost have the same size. But the loading efficiency and the release of drug in vitro was different. Conclusion： Both the two methods are suitable for preparing the lung targeted microspheres containing dexamethasone sodium phosphate. Considering the loading efficiency, the optimized o/w emulsification - evaporation method is better.

关 键 词：聚乳酸-聚乙醇酸共聚物 微球 乳化-溶剂挥发法 

分 类 号：R944.9[医药卫生—药剂学]