染色质重构因子CHD蛋白家族的研究进展  

Progress on chromatin remodeling factor CHD

作　　者：王会平[1] 徐勤枝[1] 周平坤[1] 

机构地区：[1]军事医学科学院放射医学研究所放射毒理与辐射危害评价研究室,北京100850

出　　处：《国际放射医学核医学杂志》2006年第1期42-47,共6页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金资助项目(30270423)

摘　　要：染色质重构是DNA修复、基因表达调控过程中的一个重要环节。染色质重构使染色质组织结构发生一系列重要的变化,如染色质去凝集,核小体变成开放式的疏松结构,使转录因子等更易接近并结合核小体DNA,从而调控基因转录等。CHD蛋白是目前已知的染色质重构复合物之一。目前已鉴定了6个人类CHD蛋白成员,主要有3种功能结构域:N端的两个染色质调节域,位于中部的类SWI2／SNF2 ATP酶／解旋酶域,以及C端的DNA结合域。CHD基因突变或表达异常与人类某些疾病有关。Chromatin remodeling plays an important role in DNA repair, gene transcriptional regulation. Remodeling resuhes in a series of important changes in chromatin structure, e.g. loosing the condensed chromatin and opening the structure of nucleosome, which leads to increased accessibility of the transcription factors to nucleosomal DNA. CHD （ehromodomain, heliease, DNA-binding） genes compose a subfamily of the known chromatin remodeling complexes. Up to now, six human CHD members have been cloned. They contain three main domains： Chromodomain which locates in the N terminus of the proteins, SWI2/SNF2-related ATPase/helicase domain in the middle region, DNA-binding domain in the C terminus. The mutation or abnor-mal expression of CHD gene is thought to be related to some human diseases.

关 键 词：染色质重构 ATP酶 CHD SWI2/SNF2 

分 类 号：Q51[生物学—生物化学]