Effects of two medicinal plants Psidium guajava L. (Myrtaceae) and Diospyros mespiliformis L. (Ebenaceae) leaf extracts on rat skeletal muscle cells in primary culture  

作　　者：BELEMTOUGRI R.G. CONSTANTIN B. COGNARD C. RAYMOND G. SAWADOGO L. 

机构地区：[1]Laboratory of Physiological Animal, University of Ouagadougou BP 7021, Burkina Faso [2]Institute of Physiology & Biology Cell, University of Poitiers, France

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2006年第1期56-63,共8页浙江大学学报（英文版）B辑（生物医学与生物技术）

摘　　要：Crude decoction, aqueous and ethanolic extracts of two medicinal plants （Psidiura guajava and Diospyros raespiliformis）, widely used in the central plateau of Burkina Faso to treat many diseases were evaluated for their antagonistic effects on caffeine induced calcium release from sarcoplasmic reticulum of rat skeletal muscle cells. These different extracts showed a decrease of caffeine induced calcium release in a dose dependent manner. Comparison of the results showed that Psidiura guajava leaf extracts are more active than extracts of Diospyros mespiliformis and that crude decoctions show better inhibitory activity. The observed results could explaine their use as antihypertensive and antidiarrhoeal agents in traditional medicine, by inhibiting intracellular calcium release.Crude decoction, aqueous and ethanolic extracts of two medicinal plants (Psidium guajava and Diospyros mespili- formis), widely used in the central plateau of Burkina Faso to treat many diseases were evaluated for their antagonistic effects on caffeine induced calcium release from sarcoplasmic reticulum of rat skeletal muscle cells. These different extracts showed a decrease of caffeine induced calcium release in a dose dependent manner. Comparison of the results showed that Psidium guajava leaf extracts are more active than extracts of Diospyros mespiliformis and that crude decoctions show better inhibitory activity. The observed results could explaine their use as antihypertensive and antidiarrhoeal agents in traditional medicine, by inhibiting intracellular calcium release.

关 键 词：Psidium guajava Diospyros mespiliformis MYRTACEAE EBENACEAE Medicinal plants Intracellular calcium Sarcoplasmic reticulum CAFFEINE 

分 类 号：R285[医药卫生—中药学]