急性冠脉综合征患者血清sCD40L水平动态变化与发病风险的相关性研究  

Investigation of the relationship between dynamic change of serum sCD40L and the risk of acute coronary syndrome

作　　者：陈林强[1] 何绿茵[1] 徐邦牢[1] 贝春花[1] 王蓉[1] 

机构地区：[1]广州市第一人民医院检验科,广州510180

出　　处：《江西医学检验》2006年第1期7-8,共2页Jiangxi Journal of Medical Laboratory Sciences

基　　金：广州市科技计划攻关项目(2004Z3-E0441)

摘　　要：目的研究血清sCD40L水平与急性冠脉综合征患者发病风险的相关性。方法以发生死亡或非致命性心肌梗塞为试验观察终点,依血清sCD40L水平将220例入院时胸痛时间不超过12小时的急性冠脉综合征(ACS)患者分为五组:Ⅰ组(<1.93μg/L)39例;Ⅱ组(1.93～3.50μg/L)41例;Ⅲ组(3.51～5.00μg/L)51例;Ⅳ组(5.01～6.30μg/L)46例;Ⅴ组(>6.30μg/L)43例,观察各组患者在不同随访观察时间段内发生死亡或非致命性心肌梗塞的百分率;用ELISA方法测定血清sCD40L水平。结果在最初24小时内,5个组发生死亡或非致命性心肌梗塞的百分率间差别无显著意义(P>0.05)。在随后的72小时、1个月和6个月随访观察时间内,Ⅳ组和Ⅴ组患者发生死亡或非致命性心肌梗塞的百分率均明显高于前3个组,差异有显著意义(P<0.05)。结论血清sCD40L水平增高(>5.00μg/L)的ACS患者,随观察时间的推移,发生死亡或非致命性心肌梗塞的风险增加。Objective To investigate the relationship between serum sCD40L level and the risk of acute coronary syndrome（ACS）. Methods According to the levels of serum sCD40L, the patients with ACS were categorized as five groups, as follows： 39 cases in the first group （ 〈 1.93 μg/L）, 41 in the second group （1.93 - 3.50μg/ /L）, 51 in the third group （3.51 - 5.00 μ g/L）, 46 in the fourth group （5.01 - 6.30 μ g/L）, 43 in the fifth group （〉 6.30 μg/L）. The percentages of death or nonfatal myocardial infarction in different group were observed in different period. The levels of serum sCD40L was determined by ELISA. ResultS There was not significant difference of the percentage of death or nonfatal myocardial infarction among the five groups during 24 hours（P 〉 0.05）. The results showed significant difference of the percentage of death or nonfatal myocardial infarction in the fourth and fifth groups compared with the other groups during 72 hours, 1 month and 6 months（P 〈 0.05）. Conclusions The ACS patients whose serum sCD40L levels are higher than 5.00 μg/L have the higher risk of death or nonfatal myocardial infarction with the time going on.

关 键 词：急性冠脉综合征 可溶性CD40L 风险 

分 类 号：R446.62[医药卫生—诊断学]