糖尿病早期肾损伤患者尿视黄醇结合蛋白检测的临床意义  

Determination of urine retinol binding protein and its clinical significance in patients with the early renal damage of diabetes

作　　者：曹友德[1] 李朝晖[1] 李浩[1] 

机构地区：[1]湖南省人民医院,湖南长沙410005

出　　处：《中国医学工程》2006年第1期11-13,共3页China Medical Engineering

摘　　要：目的探讨检测尿视黄醇结合蛋白(RBP)对诊断糖尿病(DM)患者早期肾损伤的临床意义。方法测定73例糖尿病患者和68例正常对照者尿中RBP、微量白蛋白(m-ALB)和N-乙酰-β-D氨基葡萄糖苷酶(NAG),并进行比较分析。RBP、mALB采用免疫比浊法测定,NAG采用终点法测定。结果尿蛋白阴性的DM1组,RBP、NAG、m-ALB高于正常对照组(P<0.05);尿蛋白阳性的DM2组,RBP、NAG、m-ALB明显高于对照组(P<0.01);DM1组与DM2组RBP、mALB和NAG比较也有差异(P<0.01)。糖尿病患者中,尿RBP的阳性率高与NAG(P<0.05)和mALB(P<0.01)。尿RBP、mALB、NAG三者之间呈明显正相关。结论RBP敏感性高于mALB、NAG,是肾小管功能的又一敏感指标。对糖尿病患者监测尿RBP、尿NAG、尿mALB水平变化,可以了解DM的早期肾损害,以达到早期诊断的目的。[Objective] To explore the clinical significance of detrmining retinal-blnding protein（RBP）in diagnosis of early renal damage in patients with diabetes. [Methods] Detecting and comparision 73 patients with diabetes and 68 controls＇ urinary RBP, microalbumin（mALB）and N-acetyl-β-D-glucosaminidase（NAG）. RBP and mALB were determind with immunothrbidimetry, NAG was determined with endpoint. [Result] The levels of urinary RBP, mALB and NAG in urinary protein negative groups of diabetes were higher than those in the controls（P〈0.05）. Urinary RBP, mALB and NAG in urinary protein positive groups of diabetes were obviously higher than those in the controls （P 〈0.01 ）arid the negative groups （P 〈0.01）. The positive rats of urinary RBP were higher than the positive rats of NAG（P 〈0.05） and mALB （P 〈0.01）in the patients with diabetes. There was significant positive conelation among the urinary RBP,mALB and NAG. [Conclusions ] The sensitivity of RBP is higher than that of mALB and NAG. RBP is another sensitive index reflecting the renal tubular function. Detecting the levels nf the urinary RBP, mALB and NAG in patients with diabetes can diagnose the early renal damage in patients with diabetes in order to ensure early diagnosis of diabetic nephropathy.

关 键 词：视黄醇结合蛋白 糖尿病 肾损伤 

分 类 号：R587.1[医药卫生—内分泌]