狼疮静颗粒对NZB/NZWF1小鼠TNF-α的影响  

Effects of langchuangjing granule on TNF-α in lupus rat model

作　　者：徐艳[1] 丁炜[1] 周定华[1] 张前德[1] 

机构地区：[1]南京医科大学第一附属医院中医科,210029

出　　处：《江苏医药》2006年第4期355-356,共2页Jiangsu Medical Journal

摘　　要：目的观察中药狼疮静颗粒(LCG)对NZB/NZWF1小鼠血清肿瘤坏死因子α(TNFα)的影响。方法将NZB/NZWF1狼疮模型鼠随机分为模型对照组、中药小剂量组、中药大剂量组和强的松组,灌胃给药54d;用双抗夹心酶联免疫吸附试验(ELISA)测定小鼠血清中TNFα的含量。结果LCG可上调NZB/NZWFI小鼠血清TNFα水平。结论中药LCG具有类激素样作用和双向免疫调节作用。Objective To investigate the effects of Chinese herbal medicine（CHM） langehuangjing granule（LCG）on serum cytokine TNF-α in rats. Methods NZB/NZW F1 rats were administered with LCG 2. 95 g/kg or 11.8 g/kg for 54 days. Prednisone was used as the positive drug. Serum TNF-α was measured by ELISA. Results LCG 11.8 g/kg up-regulated the concentration of TNF-α （P〈0.05）. Conclusion LCG has similar effect as prednisone and exerts two-ways regulation effects on the immune system.

关 键 词：狼疮静颗粒 狼疮 NZB/NZW F1小鼠 肿瘤坏死因子Α 

分 类 号：R512.3[医药卫生—内科学] R593.242[医药卫生—临床医学]