影响早产儿肺透明膜病机械通气短期预后的危险因素分析  

Analysis of risk factors of short-term prognosis for preterm infants with hyaline membrane disease requiring mechanical ventilation

作　　者：柳锡永[1] 虞如画[1] 吴莉萍[1] 

机构地区：[1]浙江义乌市中心医院新生儿科,浙江义乌322000

出　　处：《中国小儿急救医学》2006年第1期20-22,共3页Chinese Pediatric Emergency Medicine

摘　　要：目的探讨影响早产儿肺透明膜病(HMD)机械通气短期预后的危险因素。方法将47例HMD早产儿分为死亡组和存活组,用单因素χ2检验和多因素Logistic回归分析判定影响机械通气短期预后的危险因素。结果胎龄≤30周、院外出生、出生时窒息、严重酸中毒、生后未应用PS、HMD III^IV级、HMD自身及机械通气并发症、机械通气>3 d与机械通气短期预后有关(P<0.05或P<0.01)。Logistic回归分析发现HMD自身及机械通气并发症、院外出生、HMD III^IV级为机械通气短期预后的独立影响因素(OR=6.773、8.809、9.290,P均<0.05)。结论HMD自身及机械通气并发症、院外出生、HMD III^IV级是影响早产儿HMD机械通气短期预后的重要危险因素,应重视并针对危险因素加以预防。Objective To assess the risk factors of short - term prognosis for preterm infants with hyaline membrane disease（HMD）requiring mechanical ventilation. Methods 47 preterm infants with HMD were divided into death group and survival group. Potential risk factors of short - term prognosis for mechanical ventilation were studied by univariate analysis and Logistic regression analysis. Results Univariate analysis revealed that the gestational age ≤30 weeks, birth outside the hospital, asphyxia at birth, severe acidosis, nonadministration of PS, HMD grade Ⅲ-Ⅳ, complication of HMD and mechanical ventilation, duration of mechanical ventilation 〉 3 days were associated with short - term prognosis of mechanical ventilation （P 〈 0.05 or P 〈0.01）. Logistic regression analysis revealed that complication of HMD and mechanical ventilation, birth outside the hospital, HMD grade Ⅲ-Ⅳ were independent influential factors of short - term prognosis for mechanical ventilation （ OR = 6. 773 and 8. 809 and 9. 290, P （ 0.05 ）. Conclusion Complication of HMD and mechanical ventilation, birth outside the hospital, HMD grade Ⅲ-Ⅳ are important risk factors related to short - term prognosis for preterm infants with HMD requiring mechanical ventilation, more attention and prevention should be paid to risk factors.

关 键 词：婴儿 早产 肺透明膜病 机械通气 短期预后 危险因素 

分 类 号：R722.6[医药卫生—儿科]