仙鹤草、丹参在治疗心律失常中与一氧化氮(NO)关系的研究  

To study the relationship between nitric oxide and radix salviae miltiorrhizae and agrimony in treatment of arrhythmia

作　　者：杨平[1] 沈海萍[1] 张东珍[1] 李凤云[1] 

机构地区：[1]河北省人民医院,河北石家庄050000

出　　处：《中国中医基础医学杂志》2006年第2期114-115,129,共3页JOURNAL OF BASIC CHINESE MEDICINE

摘　　要：目的:研究单味中药仙鹤草、丹参在治疗心律失常中与一氧化氮(NO)的关系。方法:用实验大鼠造模预测不同剂量的作用效果分别对单味仙鹤草、丹参进行实验。结果:小剂量仙鹤草、丹参均有抗心律失常的作用,大剂量丹参有降低血脂血黏度的作用。结论:血管内皮功能的逆转,是由于内皮细胞对内环境及其分泌介质的调整所致。由此,仙鹤草、丹参抗心律失常的机制可能与NO合成与释放调节有关。Objective： To study the relationship between nitric oxide and single traditional Chinese drug radix salviae mihiorrhizae and agrimony, in treatment of arrhythmia. Methods： rats model were used to predict effects of the different dose single radix salviae miltiorrhizae and agrimony respectivelyin the study. Results： both thd lower dose radix salviae miltiorrhizae and agrimony are efficacious to antiarrhythmia. The higher salviae miltiorrhizae can reduce blood fat and viscosity. Conclusion： endothelium cells adjust millieuinterne and secreted medium result in the reverse of function of endothelium ceils. Therefore the antiarrhythmia mechanism of radix salviae miltiorrhizae and agrimony related to the synthesize and secretion of nitric oxide.

关 键 词：仙鹤草 丹参 心律失常 一氧化氮(NO) 中药调节 

分 类 号：R282.2[医药卫生—中药学]