疏肝益肾法治疗女性抑郁症30例临床研究  

Clinical Study on Method of Soothing the Liver and Tonifying the Kidney for Treatment of 30 Cases of Female Depression

作　　者：丁朝荣[1] 连方[2] 

机构地区：[1]济南市中心医院中医科,山东省济南市解放路105号250013 [2]山东中医药大学附属医院

出　　处：《中医杂志》2006年第3期202-204,共3页Journal of Traditional Chinese Medicine

摘　　要：目的:研究运用疏肝解郁、益肾宁神的原则治疗女性抑郁症后,性激素水平、汉密尔顿抑郁量表(HAMD)评分、中医临床症状评分等相关因素的变化情况。方法:按年龄、病情等因素运用分层随机分组法将60例女性抑郁症患者随机分为妇人解郁方治疗组30例和帕罗西汀对照组30例,记录治疗前后各组HAMD评分和中医症状评分并进行比较,同时测定抑郁患者与健康者的血清雌二醇(E2)、孕酮(P)和催乳素(PRL)水平。结果:生殖内分泌激素水平与HAMD评分及HAMD4因子具有相关性,经疏肝益肾法治疗后,患者血清E2显著升高(P<0.01),PRL显著下降(P<0.01)。治疗效果与帕罗西汀相当,但减轻了帕罗西汀的食欲不振、恶心呕吐等副作用。结论:生殖内分泌激素水平与抑郁症的病情严重程度具有相关性,疏肝益肾法可以调节女性抑郁症患者的性激素水平,其治疗效果显著安全。Objective： To observe changes of sexual hormone level,score for Hamilton depression scale （HAMD） and clinical score for TCM symptoms after treatment of female depression with the principle of soothing the liver and relieving depression ,and tonifying the kidney and relieving mental stress. Methods：Sixty cases of female patients of depression were randomly assigned to a treatment group （n= 30） and a control group（n= 30） according to age and condition of patients. Scores for HAMD and TCM symptoms before and after treatment were recorded and compared in both groups. Serum estradiol （Ez）, progestin （P） and prolactin （PRL） levels were determined in the patients of depression and healthy persons. Results：Hormone levels were correlated with HAMD scores and 4 factors of HAMD,and after treatment with the method for soothing the liver and tonifying the kidney,serum E2 increased （P〈 0. 01） and PRL decreased significantly （P〈 0. 01）, with a therapeutic effect similar to that of Paroxetlne, and adverse reactions of Paroxetine such as anorexia ,nausea and vomiting alleviated. Conclusion ：Female hormone levels are correlated with degrees of depression, and the method for soothing the liver and tonifying the kidney can regulate sexual hormone levels of the female depression patient, with obvious therapeutic effect and safety.

关 键 词：抑郁症/中医药疗法 疏肝 补肾 

分 类 号：R277.7[医药卫生—中医学]