慢性肺心病患者脂质过氧化损伤与病情演变的关系  

THE RELATIONSHIP BETWEEN LEVEL OF LPO AND CLINICAL DEVELOPMENT IN CHRONIC PULMONARY HEART DISEASE

作　　者：刘韵蝉[1] 虞晓红[1] 孙立[1] 席学莉[1] 唐筑灵 张晓蕾 梅元英[1] 

机构地区：[1]贵阳医学院附院 [2]贵州省老年医学研究所

出　　处：《贵州医药》1996年第2期70-71,共2页Guizhou Medical Journal

摘　　要：对64例慢性肺源性心脏病患者血清过氧化脂质（LPO）及超氧化物歧化酶（SOD）含量的检测观察。结果显示慢性肺心病患者LPO及SOD水平高于对照组，差异有显著性（P＜0．01）；肺心病急性发作期又高于缓解期．差异有显著性（P＜0．05），提示在慢性缺氧及感染状态下脂质过氧化反应增强，在肺心病的病理发展过程中可能起到一定促进作用。氧自由基（OFR）对肺组织细胞损伤的不同程度反映了肺心病病情变化的一定阶段。Detection on the quantity of lipid peroxide(LPO ) and superoxide dismutase (SOD) in sorum of 64 cases chronic pulmonary heart disease indicated that the level of LPO and SOD are higher than the control group (P <0. 01 ) and the level of LPO and SOD in atack stase of disease are higher that in remission stage (P <0. 05). It showed that LPO reaction in the state of chromic deoxygen and infection may increaesed aggravating the pathologic change, The different degree of injured lung tissue cells by oxygen free radIcal reflected the clinical development of pulmonary heart disease.

关 键 词：肺心病 过氧化脂质 超氧化物歧化酶 氧自由基 

分 类 号：R541.502[医药卫生—心血管疾病]