萘甲异喹对大鼠主动脉平滑肌^（45）Ca转运的影响  

Effects of naphthylmethyl isoquinoline on ￣(45)Ca-transportation in rat aorta

作　　者：徐济良[1] 杨毓麟[1] 关永源[1] 孙家钧[1] 

机构地区：[1]南通医学院药理教研室,广州中山医科大学药理教研室

出　　处：《中国药理学通报》1996年第1期59-61,共3页Chinese Pharmacological Bulletin

摘　　要：萘甲异喹（ＮＩ１，１０μｍｏｌ·Ｌ－１）和硝苯吡啶（Ｎｉｆ０．５μｍｏｌ·Ｌ－１）对大鼠主动脉平滑肌４５Ｃａ溢流无影响，ＮＩ（１～３０μｍｏｌ·Ｌ－１）能浓度依赖地抑制高钾和苯肾上腺素引起的大鼠主动脉平滑肌４５Ｃａ内流，抑制率分别为２７％～８１％和１７％～７７％，ＮＩ（１０μｍｏｌ·Ｌ－１）尚可明显抑制由苯肾上腺素引起的４５Ｃａ外溢。这些结果提示ＮＩ能抑制平滑肌细胞膜ＰＤＣ和ＲＯＣ两类钙通道及细胞内钙释放。The effects of naphthylmethyl isoquinoline(NI)on 45Ca flux of vascular smooth muscle in rat aorta were studied in comparison with nifedipine(Nif).NI(1,10 μmol·L-)andNif(0.5 μmol· L-1)had no effect on the resting 45Ca leak in rat aorta.NI(1～30 μmol·L-1)could decrease the45Ca influx of rat aorta induced by KCI(100 mmol·L-1)and phenylephrine(PHE 10μmol·L-1)in the concentration dependent manner.The rates of inhibition were 27%～81% and 17%～77% respectively. The effects of NI were less in potency than ones of Nif. NI(10μmol· L-1)could markedly inhibite 45Ca efflux induced by PHE(10μmol·L-1).The results indicated that NI had nonselective blocking effect between potential dependent Ca2+channels and receptor operated Ca2+ channels,and could inhibit Ca2+ release from intracellular calcium storage site.

关 键 词：萘甲异喹 血管平滑肌 钙45转运 

分 类 号：R972[医药卫生—药品]