内皮素A受体拮抗剂BQ_（123）预防内皮素－1的致心律失常作用  

Antagonistic effect of BQ_(123) on arrhythmia induced by endothelin-1

作　　者：袁文俊[1] 陈屏[1] 许金廉[1] 严云[1] 戎伟芳[1] 朱宝旺[1] 孙庆文[1] 陈建国[1] 富维骏[1] 祝元祥 

机构地区：[1]第二军医大学基础医学部生理学教研室,江南大学医疗系

出　　处：《第二军医大学学报》1996年第2期138-140,共3页Academic Journal of Second Military Medical University

基　　金："八五"全军医学科研基金

摘　　要：探明内皮素－１（ＥＴ－１）致心律失常作用的受体机制。方法：雄性ＳＤ大鼠３５只经冠状动脉口注射内皮素Ａ受体拮抗剂ＢＱ１２３，观察其对ＥＴ－１致心律失常作用的影响。结果：ＢＱ１２３０．１１～７μｇ／ｋｇ预处理后再注射ＥＴ－１引起的心律失常严重程度、发生率、死亡率呈剂量依赖性降低。ＢＱ１２３为７μｇ／ｋｇ时心律失常记分（ＡＳ）降为０，与ＥＴ－１对照组比较有非常显著差异（Ｐ＜０．０１）。结论：ＥＴ－１的致心律失常作用很可能是通过ＥＴＡ受体而介导的。Objective:To investigate the receptor mechanism of proarrhythmic action of endothelin -1(ET1).Methods:BQ123,an antagonist of ETA receptor,was administrated into coronary ostia and its effect on arrhythmia induced by ET-1 was observed in 35 male SD rats.Results:The incidence of arrhythmia,arrhythmia score(AS) and mortality induced by ET-1 were decreased dose-dependantly by pretreatment with BQ123 0.11～7μg/kg.AS was zero at the dose of BQ123 7μg/kg,and it was significantly lower than that in ET-1 control group(P<0.01). Conclusion:The results indicate that the proarrhythmic action of ET-1 is mediated by ETA receptor.

关 键 词：内皮素 受体 心律失常 拮抗剂 

分 类 号：R541.702[医药卫生—心血管疾病]