Du6859a及其他新的氟喹诺酮类药物的体外抗菌活性  

In vitro antibacterial activity of Du6859a

作　　者：汪复[1] 张敬德[1] 朱德妹[1] 王宇倩[1] 周乐[1] 张婴元[1] 

机构地区：[1]上海医科大学华山医院抗生素研究所

出　　处：《中国抗生素杂志》1996年第3期214-219,共6页Chinese Journal of Antibiotics

摘　　要：用琼脂稀释法测定Ｄｕ６８５９ａ对１２０６株临床分离菌的抗菌作用，并与其同类品种（司帕沙星、托舒沙星、诺氟沙星、氧氟沙星、左氟沙星、环丙沙星）比较。Ｄｕ６８５ｑａ对金葡球菌不产酶株、ＭＳＳＡ、ＭＲＳＡ、ＭＲＳＥ，溶血性链球菌和肺炎球菌的ＭＩＣ＿（９０）均为０．５ｍｇ／Ｌ；对肠球菌的ＭＩＣ＿（９０）为２ｍｇ／Ｌ，优于其同类品种。多数肠杆菌科细菌可为０．２５ｍｇ／Ｌ，铜绿假单胞菌可为０．５ｍｇ／Ｌ的本品所抑制，其抗菌活性与司帕沙星和托舒沙星相似。Ｄｕ６８５９ａ对各种厌氧菌亦具良好作用，多数菌株可为０．５ｍｇ／Ｌ的浓度抑制。因此认为本品具有良好的临床应用前景，值得进一步临床试验。The in vitro antibacterial activity of Du6859a against 1206 clinical isolates was studied and compared with that of sparfloxacin, tosufloxacin,norfloxacin, ofloxacin,levofloxacin and ciprofloxacin using agar dilution method.Results showed that Du6859a was highly active against Gram-positive cocci, the MIC_90s for strains of penicillinase-negative and -positive S.aureus, MRSA, MRSE were 0. 5mg/L and for strains of Enterococci 2mg/L,being the most active one among all the fluoroquinolones tested. Most straing of Enterobacteriaceae were inhibited by 0. 25mg /L and P.aeruginosa by 0. 5mg/L, Du 6859a also had strong acitvity against anaerobic organism, most strains of which were inhibited by 0. 5mg/L, Based on these data, Du6859a may be a promising agent for the treatment of various infections and further clinical trials are warranted.

关 键 词：Du6859a 氟喹诺酮类药物 抗菌活性 

分 类 号：R978.19[医药卫生—药品] R969.4[医药卫生—药学]