超声引导瘤内注射^(90)钇—高温碘油悬液治疗肝癌的疗效观察  

Ultrasound-guided hot lipiodol with ^(90)Yintratumor intra-tumor injectionon on liver cancer

作　　者：牟培源[1] 陈靖[1] 孙锁柱 王建晨[1] 蒋小良[1] 何千舸[1] 金美娟 

机构地区：[1]清华大学核能与新能源研究院 [2]解放军二炮总医院

出　　处：《山东医药》2006年第9期6-7,共2页Shandong Medical Journal

摘　　要：目的观察超声引导瘤内注射90钇(90Y)—高温碘油悬液治疗肝癌的疗效。方法在超声引导下对治疗组12例肝癌患者的27个结节行90Y—高温碘油悬液瘤内注射治疗,对照组10例肝癌患者的23个结节行90Y—普通碘油悬液瘤内注射治疗,两组每个瘤灶内均给予1ml/cm3剂量的碘油与1.0mCi/cm3剂量的90Y悬液。结果除肿瘤外,两组患者其他脏器内均未发现90Y沉积,未见有心、肺、肝、脾、肾及骨髓的异常改变。不同时间点肿瘤均呈缩小趋势,治疗后30d时治疗组肿瘤生长率为-0.47±0.17,显著低于对照组(-0.18±0.22),P<0.01;对照组肿瘤坏死范围均未超过40%;治疗组肿瘤坏死率在3、7、30d时分别为72%、81%、87%,与对照组比较,均有显著性差异(P<0.01);各时间点治疗组坏死率呈增加趋势,差异显著(P<0.05)。结论超声引导瘤内注射90Y—高温碘油悬液治疗肝癌疗效确切。Objective： To observe the effect of hot lipiodol with ^90Y intratumor injection for treatment of liver cancer. Methods： 12 patients in treatment group and 10 patients in control group were performed ultrasonically guided hot lipiodol injections （treatment group） and common lipiodol injections（control group）with radiopharmaceutical Yttrium-90 therapy. Results： No side-effect and no significant complication were observed. The tumor sizes showed a reducing trend at different time. In treatment group,the tumor growth was -0. 47±0. 17 at the 30th day after treatment, and significantly lower than that in control grout （-0. 18±0. 22） （P〈0. 01）. The tumor necrosis range was less than 40% in control group. The tumor necrosis rate in treatnent group was 72%, 81% and 87% at the 3th, 7th and 30th day respective. There was a significant difference between the two groups （ P〈0. 01）. There was a positive correlation between the necrosis rate and the time in treatment group （ P〈0. 05） Conclusion：Intratumor injection of hot lipiodol with ^90Y is a safe, feasible and effective method to treat liver cancer.

关 键 词：肝肿瘤 高温碘油 ^90钇 瘤内注射 

分 类 号：R459.6[医药卫生—治疗学] TH772[医药卫生—临床医学]