贫电子环丙烷衍生物与甲醇的反应(英文)  

Reaction of Electron-Deficient Cyclopropane Derivatives with Methanol

作　　者：周晓红[1] 曹卫国[1] 任仲皎[1] 陈杰[1] 张慧[1] 

机构地区：[1]上海大学化学系,上海200444

出　　处：《合成化学》2006年第2期139-142,共4页Chinese Journal of Synthetic Chemistry

基　　金：Supported by the National Natural Science Foundation of China(20472047)and Natural ScienceFoundation of Shanghai(20172037)

摘　　要：顺-1-呋喃乙酰基-2-对位取代苯基-6,6-二甲基-5,7-二氧-螺-[2,5]-4,8-辛二酮和顺-1-噻吩乙酰基-2-对位取代苯基-6,6-二甲基-5,7-二氧-螺-[2,5]-4,8-辛二酮与甲醇于封管中80℃反应72 h得到β-呋喃甲酰基-γ-甲氧基-γ-对取代苯基-丁酸甲酯及β-噻吩甲酰基-γ-甲氧基-γ-对取代苯基-丁酸甲酯,其结构经1H NMR,13C NMR,IR,MS及APT。讨论了反应机理。Methyl β-furoyl-γ-p-substituted phenyibutyrates or methyl β-thienoyl-γ-p-substituted phenylbutyrates was synthesized by the reaction of 1,2,3-trisubstituted electron-deficient cyclopropane derivatives cis-1-furoyl-2-p-substituted phenyl-6,6-dimethyl-5,7-dioxa-spiro- [ 2,5 ] -4,8-octadiones or cis-1 -thienoyl-2-p-substituted phenyl-6,6-dimethyl-5,7 -dioxa-spiro- [ 2,5 ] -4,8 -octadiones with methanol at 80 ℃ for 72 h in a sealed tube. The structures were confirmed by ^1 H NMR, ^13 C NMR, IR, MS and APT. The reaction mechanism for the formation of the products was also proposed.

关 键 词：取代环丙烷 丁酸甲酯 合成 

分 类 号：O624.1[理学—有机化学] O625[理学—化学]