微生物转化法合成15-羟基坎利酮  

15-Hydroxycanrenone Synthesized from Canrenone by Aspergillus ochraceus Using Microbial Transformation

作　　者：陈华明[1] 张琴[1] 李晓敦[1] 胡海峰[1] 朱宝泉[1] 

机构地区：[1]上海医药工业研究院,上海200040

出　　处：《中国天然药物》2006年第2期144-145,共2页

摘　　要：目的:应用赭曲霉羟化酶系统对坎利酮进行生物转化,合成其羟基化衍生物。方法:应用赭曲霉对坎利酮进行生物转化,获得一个硫酸显红色的产物SIPI-CANR。结果:确定SIPI-CANR化合物结构为15-羟基坎利酮。结论:赭曲霉羟化酶系统对坎利酮进行生物转化,能够合成15-羟基坎利酮,其为一新化合物。AIM： To synthesize hydroxylated derivatives of canrenone using Aspergillus ochraceus hydroxylation enzyme system by microbial transformation. METHOD： A red compound named as SIPI-CANR was obtained by bio-transforming canrenone using Aspergillus ochraceus;the purified SIPI-CANR was elucidated by spectral analysis. RESULT： The chemical structure of SIPI-CANR was elucidated to be 15-hydroxycanrenone, CONCLUSION： 15-Hydroxycanrenone can be synthesized by Aspergillus ochraceus hydroxylation enzyme system, and it is a new compound.

关 键 词：赭曲霉 坎利酮 15-羟基坎利酮 微生物转化 

分 类 号：R284.1[医药卫生—中药学] TQ460.5[医药卫生—中医学]