妊娠后期基因变异性黄体生成素是否有引起胎儿睾丸下降异常的倾向  

Does variant luteinizing hormone (V-LH) predispose to improper testicular position in late pregnancy?

作　　者：Kaleva M. Virtanen H. Haavisto A.-M. 刘凯 

机构地区：[1]Department of Physiology,University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland Dr.

出　　处：《世界核心医学期刊文摘（儿科学分册）》2006年第2期55-55,共1页

摘　　要：Undescended testes are a common urogenital malformation affecting 2-9% of newborn boys. The etiology of cryptorchidism is probably heterogeneous, but insufficient androgen effect has been recognized as one cause of the condition. A common genetic variant (V) form of LH occurs in apparently healthy individuals universally. Compared with wild-type (WT) LH, the V-LH molecule has increased bioactivity in vitro but shorter half-life in vivo. In the present study, we screened 93 cryptorchid (59 uni-and 34 bilateral) and 211 healthy boys for the occurrence of V-LH to evaluate whether it is related to testicular descent. Two immunofluorometric assays with different combinations of MAb, one detecting WT-LH, the other detecting bothWT-and V-LH, were used to measure LH concentrations. The ratio of two LH measurements was used to assess the V-LH status. The prevalence of V-LH was similar in the control and cryptorchid groups, and the total prevalence of V-LH corresponded well to the prevalence of V-LH in general Finnish population. Among cryptorchid boys, the prevalence of V-LH was dependent on gestational age: 6.7% at GA < 37, 20.9% at GA 37-39, and 42.9% at GA of 40-42 wk. In contrast, the percentage of V-LH status was similar at different gestational ages in all control groups. We conclude that V-LH is not critical for normal testicular descent but the increased prevalence of V-LH among cryptorchid boys with GA >40, suggests that the lower hormonal efficacy of V-LH predisposes for improper testicular descent in late pregnancy.Undescended testes are a common urogenital malformation affecting 2- 9% of newborn boys. The etiology of cryptorehidism is probably heterogeneous, but insufficient androgen effect has been recognized as one cause of the condition. A common genetic variant （V） form of LH occurs in apparently healthy individuals universally. Compared with wild-type （WT） LH, the V-LH molecule has increased bioactivity in vitro but shorter half-life in vivo. In the present study, we screened 93 cryptorehid （59 uni- and 34 bilateral） and 211 healthy boys for the occurrence of V-LH to evaluate whether it is related to testicular descent. Two immunofluorometric assays with different combinations of MAb, one detecting WT-LH, the other detecting both- WT- and V-LH, were used to measure LH concentrations. The ratio of two LH measurements was used to assess the V-LH status. The prevalence of V-LH was similar in the control and cryptorchid groups, and the total prevalence of V-LH corresponded well to the prevalence of V-LH in general Finnish population. Among cryptorehid boys, the prevalence of V-LH was dependent on gestational age：

关 键 词：黄体生成素 基因变异性 睾丸下降 妊娠后期 免疫荧光检测法 泌尿生殖系统畸形 异常 胎儿 单克隆抗体 隐睾症 

分 类 号：R711.75[医药卫生—妇产科学] R378.3[医药卫生—临床医学]