我国婴儿早产部分危险因素的Meta分析  

META-ANALYSIS OF SOME RISK FACTORS OF PREMATURE DELIVERY.

作　　者：张俊辉[1] 潘晓平[1] 张青碧[2] 叶运莉[2] 

机构地区：[1]四川大学华西公共卫生学院卫生统计学教研室 [2]泸州医学院公共卫生系

出　　处：《现代预防医学》2006年第3期272-274,共3页Modern Preventive Medicine

摘　　要：目的:综合评价早产与其危险因素的关联性。方法:应用Meta分析方法对已发表的10篇关于早产危险因素的病例对照研究文献进行综合分析,共累积病例1 257例,对照1 511例。根据齐性检验结果决定采用何种模型来计算OR及其95%可信区间,若同质选用固定效应模型,若不同质选用随机效应模型。结果:胎膜早破、妊高征、前置胎盘、多胎、胆淤症5个研究因素的合并OR及其95%可信区间分别为4.11(3.22,5.23)、3.14(1.45,6.79)、13.02(5.71,29.72)、3.94(1.91,8.11)和21.85(6.38,74.80)。结论:早产与胎膜早破、妊高征、前置胎盘、多胎、胆淤症有关。Objective： To evaluate the association between premature delivery and its risk factors. Methods： The results of 10 case-control studies from 1989 to 2004 were analyzed by meta- analysis method in this study. The cumulative cases and controls were 1257 and 1511 respectively. The calculation method of the merged OR and 95% Confidence Interval were decided by the result of homogeneity test. When H0 was rejected, fixed effect model was adopted. When H0 was accepted, random effect model was adopted. Results： The merged OR values and their 95% CI were 4.11 （3.22, 5.23）, 3.14 （1.45, 6.79）, 13.02 （5.71, 29.72）, 3.94 （1.91, 8.11） and21.85 （6.38, 74.80） respectively. Conclusion： Premature rupture of the membranes, pregnancy induced hypertension, placental presentation, idiopathic cholestasis of pregnancy and multiple birth were considered risk factors of premature delivery.

关 键 词：早产 危险因素 META分析 

分 类 号：R722.6[医药卫生—儿科]