祛斑乳膏的研制及质量控制  

Preparation and quality control of Quban emulsion

作　　者：姜芳宁 张玉叶[1] 刘光斌[1] 刘效栓[1] 郑旭东[1] 

机构地区：[1]嘉峪关市酒钢医院药学部,甘肃嘉峪关735100

出　　处：《兰州大学学报（医学版）》2006年第1期70-72,共3页Journal of Lanzhou University（Medical Sciences）

摘　　要：目的研制祛斑乳膏的处方和制备工艺,并建立制剂的含量测定方法。方法以维甲酸(0．05％)、氢醌(4％)、曲安缩松(0．1％)、维生素E(0．3％)为主要成分制备祛斑乳膏,采用紫外分光光度法控制制刺中维甲酸的含量。结果本制剂中维甲酸的平均回收率为100．94％(RSD=0．21％)。结论所得制剂性质稳定．建立的质控方法可靠,满足了临床治的需要。Objective To study the prescription and preparation technics of emulsion, and establish a method for determining its contents. Methods Quban emulsion was prepared mainly with retinoic acid（0.05%）, hydroquinone（4%）, triamcinolone（0.1%）, acetonide vitamine E（0.3%） and emulsifier. Contents of retinoic acid were determined by UV spectrophotometry. Results The average recoveries of retinoic acid was 100.94% with RSD=0.21%. Conclusion Quban emulsion has good stability, and its quality can be controlled. It is a useful preparation for the clinical treatment of chloasma.

关 键 词：祛斑乳膏 维甲酸 紫外分光光度法 制备工艺 

分 类 号：R283[医药卫生—中药学]