万拉法新对抑郁症注意网络功能的影响  

Effects Of Venlafaxine For The Attention Networks Of Depression Disorder

作　　者：杜静[1] 汪凯[1] 董毅[2] 范津 

机构地区：[1]安徽医科大学第一附属医院神经心理学实验室,合肥230022 [2]安徽省精神卫生防治中心,合肥230022 [3]Department of Psychiatry Mount Sinai School of Medicine

出　　处：《心理学报》2006年第2期247-253,共7页Acta Psychologica Sinica

基　　金：国家自然科学基金(30370479);安徽省自然科学基金(01043602);安徽省教育厅自然科学基金重点项目(2004kj192zd)

摘　　要：目的研究抑郁症的注意网络状况及抑制神经递质再摄取的药物万拉法新对其的影响,探索神经递质与注意网络的关系。方法对32例应用万拉法新治疗的抑郁症患者治疗前及疗后6周进行注意网络测定和临床症状评分。结果与正常组比较,抑郁组的警觉网络和执行控制网络效率差异有显著性,定向网络效率差别无显著性。警觉网络效率与HAMD评分的睡眠障碍因子分呈负相关。治疗后,抑郁组的警觉效率显著增加,其改善与睡眠障碍的好转呈正相关。执行控制网络效率,平均反应时和临床症状评分均较治疗前显著降低,定向网络效率无变化。结论抑郁症患者存在警觉和执行控制注意网络的异常,万拉法新可选择性地改善警觉和执行控制注意网络的异常而不影响其定向网络。To estimate attention networks in patients with depression and the effects of venlafaxine （ selective noradrenergic and serotonin reuptake inhibition ） on them. 32 Patients met CCMD-3 criteria for major depression were treated with venlafaxine and were tested with attention networks test, SDS, HAMD before and after 6 weeks. Compared with control, the alerting and executive control attention networks effects were significantly changed while the orienting network effects were not differences. The alerting network effects were negatively correlated with the factor 6 （sleep disturbance） in HAMD. After treatmeant, the alerting effects were significantly increased, these changes were positive correlated with the improvement of factor 6. The executive control network effects, SDS and HAMD were significantly reduced. The orienting effects were not changed. Depression patients suffered alerting and executive control networks deficits which were correlated with symptoms. Venlafaxine selectively impacted the alerting and executive control attention networks in depression, but had no effects on orienting network.

关 键 词：抑郁症 注意网络测试 万拉法新 

分 类 号：B845.4[哲学宗教—心理学]