不同剂量慢性染氟对大鼠学习记忆行为的影响  

The Influence of Drinking Different Concentration of NaF on Learning-memory Behaviors of Rats in the Brain

作　　者：王国明[1] 李积胜[2] 周红军[1] 朱建忠[1] 

机构地区：[1]沧州医学高等专科学校药理教研室,河北沧州061001 [2]武警医学院军事预防医学研究所,天津300162

出　　处：《微量元素与健康研究》2006年第2期1-2,共2页Studies of Trace Elements and Health

基　　金：国家自然科学基金资助项目(39870689)

摘　　要：目的:探讨不同剂量慢性染氟对大鼠学习记忆能力的影响。方法:选用Wistar大鼠46只,随机分为对照组、低氟组、高氟组3组,分别饮用自来水(对照组),100 mg/L(低氟组),200 mg/L(高氟组)的氟化钠溶液,5个月后用Y—迷宫实验观察慢性氟中毒对大鼠学习记忆行为的影响。结果:与对照组大鼠Y—迷宫实验学会所需次数(58.83±25.12)相比,低氟组(73.95±9.77)和高氟组(77.37±8.69)的大鼠学会所需次数明显增加(P<0.05),且随染氟剂量的增加学会所需次数亦增加,但无统计学意义(P>0.05)。结论:提示慢性氟中毒对大鼠学习记忆能力有显著的影响。Objective：It was observed that the influence on the capability of learning - memory behavior of rats were assessed. Method： In choosing 46 Wistar rats were divided into three group： the control group , the low fluorine group, the high fluorine group, then given byl00mg/L and 200mg/L NaF solution and free water （control group ） respectivdy, five months later, the influences of drinking different concentration of NaF on the capability of learning - memory behavior of rats were assessed by using Y - maze. Results： In contrast to the control group, the learning times of Y-hbyrinth experiment of 100mg/L and 200mg/L NaF solution were higher than control group（P 〈 0.05 ） , which related with the consistence of fluorine to a certain extent. Conclusions： Fluorosis had significant damages on the rats＇ capacity of learning-memory.

关 键 词：氟中毒 学习记忆 Y-迷官 

分 类 号：O613.41[理学—无机化学] Q959.836[理学—化学]