动物乳腺生物反应器研究进展  

New Advances in Mammary Gland Bioreactor

作　　者：袁建民[1] 胡建宏[2] 李青旺[2] 贾永红 王立强[2] 

机构地区：[1]陕西省白水县家畜改良站,陕西白水715600 [2]西北农林科技大学动物科技学院,陕西杨凌712100 [3]陕西省家畜改良站,陕西泾阳713702

出　　处：《中国农学通报》2006年第3期20-24,共5页Chinese Agricultural Science Bulletin

基　　金：河北秦皇岛科技局――利用转基因羊生产基因工程药物(DT83)研究内容。

摘　　要：动物乳腺生物反应器拥有巨大的开发价值,利用转基因家畜的乳腺生产人类重组蛋白,可以获得安全而有效的药用蛋白。在此,在阐述乳腺生物反应器概念的基础上,探讨了乳腺生物反应器医用蛋白产品、载体构建以及转基因技术等方面的研究现状,并指出了乳腺生物反应器存在的主要问题,展望了发展前景,特别是指出了利用体细胞克隆技术生产乳腺生物反应器的优势及可能性。The mammary gland bioreactor has great commercial value. The production of human recombinant proteins in milk of transgenic farm animals offers a safe, very cost-effective source of commercially proteins that cannot be produced as efficiently in adequate quantities by other methods. Based on brief illustration to the concept of mammary gland bioreactor, this review has summarized the current status of biopharmaceutical protein, vector construct, transgenic methods, economics, and obvious potential in transgenic animals bioreactors. At the same time, present problems and prospects in mammary gland bioreactor were put forward. Recently, a more powerful approach was adopted in the transgenic animals founded on the application of cloning of somatic cells, which will offer advantages and unprecedented possibilities for generating transgenic animals.

关 键 词：转基因动物 乳腺生物反应器 体细胞克隆 研究进展 

分 类 号：Q78[生物学—分子生物学] TQ460.38[化学工程—制药化工]