Aquaporins as potential drug targets  

作　　者：Fang WANG Xue-chao FENG Yong-ming LI Hong YANG Tong-hui MA 

机构地区：[1]Membrane Channel Research Laboratory, Northeast Normal University, Changchun 130024, China

出　　处：《Acta Pharmacologica Sinica》2006年第4期395-401,共7页中国药理学报（英文版）

基　　金：Project supported by the National Natural Science Foundation for Distinguished Young Scholars(No 30325011);National Natural Science Foundation(No 30470405);Distinguished Young Scholars Foundation of Jilin Province(No 20030112);Excellent Young Teachers Program of Ministry of Education,China.

摘　　要：The aquaporins （AQP） are a family of integral membrane proteins that selectively transport water and, in some cases, small neutral solutes such as glycerol and urea. Thirteen mammalian AQP have been molecularly identified and localized to various epithelial, endothelial and other tissues. Phenotype studies of transgenic mouse models of AQP knockout, mutation, and in some cases humans with AQP mutations have demonstrated essential roles for AQP in mammalian physiology and pathophysiology, including urinary concentrating function, exocrine glandular fluid secretion, brain edema formation, regulation of intracranial and intraocular pressure, skin hydration, fat metabolism, tumor angiogenesis and cell migration. These studies suggest that AQP may be potential drug targets for not only new diuretic reagents for various forms of pathological water retention, but also targets for novel therapy of brain edema, inflammatory disease, glaucoma, obesity, and cancer. However, potent AQP modulators for in vivo application remain to be discovered.The aquaporins （AQP） are a family of integral membrane proteins that selectively transport water and, in some cases, small neutral solutes such as glycerol and urea. Thirteen mammalian AQP have been molecularly identified and localized to various epithelial, endothelial and other tissues. Phenotype studies of transgenic mouse models of AQP knockout, mutation, and in some cases humans with AQP mutations have demonstrated essential roles for AQP in mammalian physiology and pathophysiology, including urinary concentrating function, exocrine glandular fluid secretion, brain edema formation, regulation of intracranial and intraocular pressure, skin hydration, fat metabolism, tumor angiogenesis and cell migration. These studies suggest that AQP may be potential drug targets for not only new diuretic reagents for various forms of pathological water retention, but also targets for novel therapy of brain edema, inflammatory disease, glaucoma, obesity, and cancer. However, potent AQP modulators for in vivo application remain to be discovered.

关 键 词：AQUAPORINS membrane water permeability fluid transport MUTATION gene knockout gene function human disease drug discovery 

分 类 号：R9[医药卫生—药学]