茶碱对慢性哮喘和肺功能改善的作用  

Clinical efficacy of low-dose oral theophylline for treating mild asthma

作　　者：黄少丹[1] 阳隽[1] 张世叶 田利奇[1] 潘巧红[1] 

机构地区：[1]广州医学院第二附属医院呼吸科,广东广州510260 [2]广州市第二人民医院呼吸科,广东广州510150

出　　处：《南方医科大学学报》2006年第3期325-327,共3页Journal of Southern Medical University

基　　金：广东省医学科研项目(A2001267)~~

摘　　要：目的了解茶碱在慢性哮喘轻症患者临床症状缓解和气道炎症抑制作用的机制。方法选择41例慢性哮喘的第1级及第2级中的轻症患者,口服缓释茶碱每天4￣6mg/kg.b.w.,每12 h 1次,连用16周。对照组15例,未服药治疗。对比评估临床症状,检测晨间最大呼气流黄(PEFam)、用力肺活量(FVC)、1秒钟用力呼气容积(FEV1)、1秒钟用力呼气容积降低20%所需药物累积量(PD20),静脉血T细胞亚群(CD3+、CD4+、CD8+)的变化。结果经茶碱口服治疗后,临床症状评分、PD20、PEFam、FEV1,CD3+、CD4+与对照组比较差异有显著意义。结论慢性哮喘轻症患者小剂量茶碱口服治疗16周后,哮喘患者临床症状有明显改善,气道高反应性与对照组比较得到改善(P<0.01)。Objective To observe the role of theophylline in relieving airway symptoms and inflammation in patients with mild asthma. Methods Fifty-six patients with mild asthma were randomly divided into treatment group （n=41） receiving oral theophylline at daily dose of 4 to 6 mg/kg for 16 weeks and control group （15 cases） without medication other than β2 antagonist, which was administered when necessary in both groups. Peripheral blood T-lymphocyte subsets （CD3^＋, CD4^＋, and CD8^＋） and pulmonary function （PEFam and PD20） before and at 8 and 16 weeks during treatment were measured. Results Significant difference was observed in CD3^＋ and CD4^＋ T-lymphocyte subsets after medication with theophyllme （P〈0.05） in the patients, and PEFsm and PD30 were also significantly different from those of the control group （P〈0.05）. Theophyllme significantly improved the clinical symptom scores （P〈0.05） and decreased the asthma attacks. Conclusion Low-dose oral theophylline may significantly relieving airway inftarmnation in patients with mild asthma.

关 键 词：茶碱 哮喘 气道炎症 

分 类 号：R562.25[医药卫生—呼吸系统]