局限性肌张力障碍的手术治疗分析  

A study on outcome of surgical treatment for focal dystonia

作　　者：张宇清[1] 李勇杰[1] 张晓华[1] 

机构地区：[1]首都医科大学宣武医院北京功能神经外科研究所,100053

出　　处：《中华外科杂志》2006年第6期420-422,共3页Chinese Journal of Surgery

基　　金：首都医学发展基金资助项目(2002-3023)

摘　　要：目的探讨立体定向核团毁损手术治疗局限性肌张力障碍的疗效。方法23例局限性肌张力障碍患者按照病因分成两组,A组原发性患者10例,B组继发性患者13例。采用立体定向核团毁损手术治疗。术后随访6个月,观察并对比运动功能改善情况。结果A组患者均得到治愈。B组患者平均改善率43.8%,个体间疗效差别较大。结论立体定性丘脑腹外侧核毁损手术是治疗书写痉挛的有效手段。继发性局限性肌张力障碍的手术疗效取决于脑功能损害的广泛程度,有无病灶不一定是手术预后的指标。Objective To analysis the outcome of stereotactic nucleus lesioning for focal dystonia patients. Methods Twenty-three focal dystonia patients were divided into 2 groups according to etiological factor. Stereotactic nucleus lesioning was performed for 10 primary dystonia patients of group A and 13 secondary patients of group B. The change of motor function was investigated and matched between 2 groups after 6 months follow-up. Results Significant improvement of motor abilities was observed in patients of group A. The mean improvement of patients of group B was 43.8%. And the individual difference of improvement was obvious in patients of group B. Conclusions Stereotactic nucleus lesioning displays a satisfactory therapeutic effect for patients of writer＇s cramp. The efficacy of nucleus lesioning for secondary focal dystonia patients depends on the extensive of brain functional lesion. A structurally normal brain is not certainly a predictor of good response to surgical treatment.

关 键 词：张力失调 立体定向技术 核团毁损 

分 类 号：R651[医药卫生—外科学]