速效感冒片中扑热息痛与咖啡因含量测定的一种新方法  

A New Method of Content Mensuration of Paracetamol and Caffeinein Tablet of New Quick Acting Common Cold

作　　者：王亚楠[1] 张海龙[2] 高东红[3] 

机构地区：[1]北京大学医学部基础01级,北京100083 [2]北京大学医学部临床2001-3班,北京100083 [3]北京大学医学部生物数学与生物统计教研室,北京100083

出　　处：《数学的实践与认识》2006年第3期123-126,共4页Mathematics in Practice and Theory

摘　　要：扑热息痛和咖啡因是速效感冒片中的主要成分,其含量决定了速效感冒片的药效及副作用的大小.我们通过实验分别做出一定浓度扑热息痛溶液和咖啡因溶液的紫外吸光度随检测波长的变化曲线(λ-A曲线),并用M athem acica软件中曲线拟合的方法分别求出上述两条变化曲线的拟合方程,以这两个方程的线性组合形式拟合速效感冒片溶液紫外光谱的λ-A曲线,根据系数的比例关系求得扑热息痛和咖啡因在速效感冒片中的含量.简化了传统双波长法的操作,提高了检测速度.Paracetamol and caffeine are the main ingredients of tablet of new quick acting common cold, whose content determine the pharmic and side effects. From our experiment, we get a curve, which describes the relationship between the ultraviolet absorption of paracetamol and caffeine solution and detective wave length （λ-A curve）. We utilize the method of curvefit in Mathematica software to get two equations describing two curves, separately. Then we use the line conbination of equations above to fit the λ-A curve in ultraviolet spectrum of the solution of tablet of new quick acting common cold, and get the content of paracetamol and caffeine according to the proportion of tb coefficient. It simplify the traditional two-wavelength method, and accelerate the mensuration velocity.

关 键 词：MATHEMATICA 曲线拟合 药物含量测定 

分 类 号：R927[医药卫生—药学]