冠心病人群血清NO、ET、hs-CRP、TNF-α和脂联素水平的相互关系  

Relationship Among NO,ET,hs-CRP,TNF-α and Adiponectin Levels in Coronary Heart Disease

作　　者：郁志明[1] 张笛[1] 洪侃[1] 薛一峰[1] 宫玲玲[1] 李嘉萍[1] 陆卫红[1] 冯健[1] 

机构地区：[1]江南大学附属无锡市第五人民医院心内科,江苏无锡214071

出　　处：《标记免疫分析与临床》2006年第1期4-6,3,共4页Labeled Immunoassays and Clinical Medicine

基　　金：无锡市卫生局课题基金(NO.2004-00115)

摘　　要：为探讨冠心病人群中血清一氧化氮(NO)、内皮素(ET)、高敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、脂联素和胆固醇(TC)水平并分析其相互之间的关系,本文选定对照组(A组)20名、单纯冠心病组(B组)32例和冠心病伴高胆固醇血症组(C组)36例,对上述指标进行检测。结果表明:ET:B组(66.5±48.3pg/mL)、C组(73.2±53.8pg/mL)与A组(50.1±20.7pg/mL)比,分别P<0.01和P<0.001;hs-CRP:B组(2.18±2.02mg/dL)、C组(3.08±2.73mg/dL)与A组(1.46±1.26mg/dL)比,P均小于0.001;TNF-:αB组(19.0±7.0pg/mL)、C组(25.0±9.0pg/mL)与A组(15.0±5.0pg/mL)比,P均小于0.001;NO:B组(43.5±22.7μmol/L)、C组(40.1±20.3μmol/L)与A组(75.4±40.6μmol/L)比,P均小于0.001;脂联素:B组(8.58±2.72mg/L)、C组(7.08±2.03mg/L)与A组(12.46±3.26mg/L)比,P均小于0.001。血清脂联素水平和冠状动脉狭窄程度呈负相关(P<0.01)。在以TC为应变量的多元回归分析中,hs-CRP、脂联素进入方程(P<0.001)。冠心病人群的血清ET、hs-CRP、TNF-α水平显著高于非冠心病人群,血清NO、脂联素水平则与之相反。脂联素和TC、hs-CRP同样是一个很好的评价冠心病冠状动脉粥样硬化严重程度的指标。To measure NO, ET, hs-CRP , TNF-α and adiponectin levels and to analyse relationships among them in 68 patients with coronary heart disease（CHD） and 20 control subjects （group A）, the coronary heart disease subjects according to their blood total cholesterol（TC） level were divided into simple CHD group （B, n=32） and CHD with hypercholesterolemia group （C, n= 36）. Fasting TC, NO, ET, hs-CRP, TNF-α and adiponectin concentrations were measured in all subjects. The relationships among these factors were analyzed . The ser um ET, hs-CRP, TNF-α levels in group B were significantly higher than those in group A, while serum NO and adiponectin levels were significantly lower in group B than those in group A. Adiponectin level was significantly correlated with coronary artery stenosis degree. TC, hs- CRP and adiponectin levels are good indexes in evaluating the CHD.

关 键 词：冠心病 胆固醇 一氧化氮 内皮素 高敏C反应蛋白 肿瘤坏死因子口 脂联素 

分 类 号：R541.4[医药卫生—心血管疾病]