ANCA与内科疾病的相关性  

RELATIONSHIP BETWEEN ANCA AND MEDICAL DISEASES

作　　者：陈素英[1] 戴慧莉[1] 钱家麒[1] 吴青伟[1] 

机构地区：[1]上海第二医科大学仁济医院

出　　处：《上海医学》1996年第7期380-383,共4页Shanghai Medical Journal

摘　　要：本文检测了１７０例内科疾病患者血清，结果表明一般内科疾病不存在或极少存在ＡＮ－ＣＡ，其阳性率较低（８．３３％），且所有的阳性病例都伴有感染。ＡＮＣＡ在风湿病患者血清中阳性率为７０．０％，常与抗核抗体和抗组蛋白抗体有交叉重叠现象。在肾脏疾病中ＡＮＣＡ阳性检出率为７２．８５％，其分布较广泛，多见于新月体肾小球肾炎、紫癜性肾炎、ＩｇＡ肾病和局灶节段性肾小球硬化，但也可见于微小病变性肾病、急性间质性肾炎、肾小球终末期病变等疾病中，因此我们认为肾组织学检查仍不可缺少，同时，作者对检测方法和病理学检查及治疗方案也进行了讨论。o determinate the relationship between ANCA and medical diseases, the authers inves-tigate the sera of 170 medical patients。 The results showed that little ANCA were presentedin patients with general medical diseases. The ANCA positive rate was low(8,33%),all thepositive cases were comaplicated by infections. The positive rate was 70.0%in patients withrheumatic diseases, and ANCA was usually overlapped with anti-nuclear and anti-histoneantibodies。 In renal diseases the ANCA positive rate was 72.85%with wide distribution。ANCA occurs most often in crescent glomerulonephritis,Henoch-Schonlein purper,IGAnephropathy and focus segmental glomerulonephritis,but can also be seen in minimal changenephropathy, acute interstitial glomerulonephritis,end-stage glomerular diseases etc. Sowe suggest that it’s still necessary to do renal histological examination。In this paper the au-thors also discuss the methods of detection,pathological examination and therapy.

关 键 词：抗中性粒细胞 胞浆抗体 内科疾病 肾脏疾病 

分 类 号：R510.3[医药卫生—内科学] R692.03[医药卫生—临床医学]