维生素C及辅酶Q_(10)治疗前后乙醇对兔心脏超声参数的影响  

The Effect of Alcohol on Cardiac Ultrasonic Parameter in Rabbits before and after Treatment with Vitamin C and Coenzyme Q_(10)

作　　者：冯庆芝[1] 

机构地区：[1]山东省菏泽市立医院急诊科,274031

出　　处：《中国误诊学杂志》2006年第5期815-817,共3页Chinese Journal of Misdiagnostics

摘　　要：目的:观察乙醇对兔心脏超声参数LVPW d、LV Sd、LVD d、FS%、EF%、E、A及E/A比值的影响及维生素C、辅酶Q10治疗的效果。方法:将30只白色獭兔随即分为3组,1组(正常对照组):正常饲喂30 d做超声心动图;2组(饲喂乙醇组):饲喂乙醇30 d做超声心动图;3组(干预治疗组):饲喂乙醇30 d停喂乙醇加喂维生素C、辅酶Q1015 d,做超声心动图。结果:2组心脏超声参数EF%、FS%、E、E/A比值明显低于1组及3组(P<0.05);LVPW d、LV Sd、LVD d、A值明显高于1组及3组(P<0.05);3组与1组相比上述心脏超声参数可见明显差异(P<0.05)。结论:乙醇可以降低兔心脏的收缩功能及舒张功能;维生素C、辅酶Q10对酒精性心肌病具有保护作用,可逆转心功能下降。Objective： To observe the effect of alcohol on the ultrasonic parameters, such as LVPWd, LVSd, LVDd, FS%, EF%, E,A and E/A in rabbit heart, and the therapeutic effeets of vitamin C and eoenzyme Q10. Methods： 30 white otter rabbits were randomly divided into three groups. In group Ⅰ （the control group）, Echocardiographs were detected after the rabbits had been fed with normal diet for 30 days, in group Ⅱ （the alcohol group）, Eehocardiographs were detected after fed with alcohol for 30 days, and in group Ⅲ （the treatment group）, echoeardiographs were detected after fed with alcohol for 30 days followed by vitamin C and coenzyme Q10 for another 15 days. Results： The ultrasonic parameter values such as EF%, FS%, E, E/A of group Ⅱ were statistically lower than those of group Ⅰ and group Ⅲ （P 〈 0.05）, respectively, while the values of LVPWd, LVSd, LVDd, A were statistically higher than those of group Ⅰ and group Ⅲ （P〈0.05）, respeetively, and significant differenee was found between of group Ⅲ and group Ⅰ in these parareenters. （P〈0.05）. Conclusions： Alcohol ean decrease the systolic function and diastolic function of heart. Vitamin C and eoenzyme Q10 have protective effects in alcoholic cardiomyopathy, can reverse the decreases of cardiac function.

关 键 词：心肌病 酒精性/药物疗法 超声心动描记术 抗坏血酸/治疗应用 泛醌/治疗应用 

分 类 号：R542.205.3[医药卫生—心血管疾病]