抗肝硬化复方的活血化瘀作用  

The blood-activating and stasis-eliminating effect of BJ-JN

作　　者：吴樱樱[1] 胡秀萍[1] 朱虹[1] 徐明[1] 邹宇宏[1] 邝荔香[1] 杨雁[1] 陈敏珠[1] 

机构地区：[1]安徽医科大学药理学教研室,合肥230032

出　　处：《安徽医科大学学报》2006年第2期161-163,共3页Acta Universitatis Medicinalis Anhui

基　　金：安徽省教育厅自然科学基金(编号:2002kj152)

摘　　要：目的观察抗肝硬化复方(BJJN)抗胆汁淤积性肝硬化的活血化瘀作用。方法利用胆总管结扎术(BDL)制备大鼠肝脏胆汁淤积性肝硬化模型,于造模第4周起ig给予BJJN3、6、12g/(kg·d)和阳性对照药肝灵8g/(kg·d),连续14d。检测各组大鼠的腹水量,24h尿钠、钾的排泄量,以及全血黏度值,血浆黏度值和全血高切、低切相对黏度等血液流变学指标。结果BJJN3个剂量组均能显著减少肝硬化大鼠的腹水量,明显增加24h尿钠、钾的排泄量。BJJN低剂量明显降低mPas3、mPas4,BJJN中剂量明显降低mPas1,BJJN高剂量组能明显降低4种不同切变率(1/200s、1/30s、1/5s、1/1s)的全血黏度值,BJJN中、高剂量组均使血浆黏度值mPas(切变率1/100s)明显降低。结论BJJN3个剂量(3、6、12g/kg)明显改善胆总管结扎术所致肝硬化大鼠腹水量、24h尿钠与钾的排泄量、血流变改变,该作用可能与其活血化瘀作用有关。Objective To explore the blood-activating and stasis-eliminating effect of BJ-JN on hepatic cirrhosis of cholestasis. Methods The rat model of hepatic cirrhosis of cholestasis was induced by common bile duct ligation （BDL）. The amount of ascites and the samples of urine and blood were measured. Results The amount of ascites of rats was reduced significantly by BJ-JN （3,6,12 g/kg）. The total amount of potassium and sodium excreted from urine for 24 hours was increased significantly by BJ-JN （3,6,12 g/kg）. The elevated viscosity of whole blood either mPas3 and mPas4 was decreased significantly by 3 g/kg of BJ-JN or mPasl by 6 g/kg of BJ-JN. The shear rates elevated after BDL, including 1/200,1/30,1/5,1/1 s, were decreased significantly by BJ-JN （12 g/kg）. The elevated plasma viscosity （shear rate 1/100 s）was also decreased significantly by BJ-JN （6,12 g/kg）. Conclusion The results suggest that BJ-JN play a role in improving the changes of ascites, potassium and sodium excreted from urine for 24 h, and the hemorheology, which might be associated with the blood-activating and stasiseliminating.

关 键 词：肝硬化 胆汁性/中药疗法 活血祛瘀剂/治疗应用 血液流变学 

分 类 号：R287[医药卫生—中药学] R575.22[医药卫生—中医学]